Graphical abstract showing gradient distribution of primary cilia in the mural cells. Primary cilium frequency and lengths are reversely proportional to smooth-muscle actin expression.

🧩 Summary:
✅ #Pericytes have #PrimaryCilia with an arterio-venular gradient🏳️‍🌈
✅ 🚶‍♀️🧠 ECs have primary #cilia, 🐁🧠 ECs don’t
✅ EC polarity aligns opposite to #BloodFlow 🧭
❔Lots of open questions about cilia’s role in #NeurovascularCoupling!
Read the full preprint: 🔗 www.biorxiv.org/content/10.1...
🧪🧵8/8

In 🐁, some #pericyte #PrimaryCilia penetrate #astrocytic #endfeet and reach the #neuropil - sometimes near #synapses! Could these #cilia act as sensory “antennae” 📡for #NeurovascularCoupling?
🧪🧵5/8

In vivo two-photon microscopy for studies of #NeuroVascularCoupling in rodents

(More than) a beginner’s guide🫡

Likely adaptable for skeletal muscle with second skin window😁

#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...

NIH-funded science that:
🇺🇸 Builds foundational knowledge for brain disease diagnostics
🎓 Trains next-gen neuroengineers
⚙️ Keeps the U.S. leading in neurotechnology innovation

#Neuroengineering #fMRI #NeurovascularCoupling #NIH #BrainResearch #ScienceForAmerica

Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study AbstractStudy Objectives. Cerebrovascular events are more frequent in the morning, coinciding with disturbed circadian rhythms and poor sleep quality. Neur

This study explores whether #NeurovascularCoupling (NVC), a marker of neuronal activity and endothelium-dependent cerebrovascular function, shows circadian variation and whether it is associated with sleep quality.
academic.oup.com/sleep/articl...

Global & Arteriole-capillary transition zone #NeuroVascularCoupling imaged by #UltrasoundLocalizationMicroscopy😆

Adult endothelial Eng KO🐭
👉Arteriole dilation+tortuosity
👉Ensheath/Mesh Pericyte soma rounding
👉⏬Sensory🧠flow

@mickaeltanter.bsky.social #NatBME ‬2025
link.springer.com/article/10.1...

Wake up moment!!! 🎥✨
#Astrocyte calcium bursts light up as the brain shifts from sleep to wakefulness in postnatal mice. 👉 Pay attention to the glowing #vasculature. ⚡
#NeonatalBrain #NeurovascularCoupling #liveimaging @ucoimbra.bsky.social @lacaixa.bsky.social

We challenged mice with acute #BloodPressure spikes (~70% increase via angiotensin II). Result: both adult and #old mice got their #MyogenicResponse and #NeurovascularCoupling disrupted

NIRS fNIRS e Depressão Cortical Propagada NIRS fNIRS e Depressão Cortical Propagada

NIRS fNIRS e Depressão Cortical Propagada
#NIRSfNIRS
#Neurociência
#BrainResearch
#CognitiveScience
#FunctionalImaging
#NIRS
#fNIRS
#NeurovascularCoupling
#BrainOxygenation
#BrainActivity
#Neuromodulation
#CognitivePerformance
#Decolonial
#Neuroscience

neuroinsight.net/blog/nirs-fn...

Looking forward to next weeks BRAIN MICROCIRCULATION -
CTH workshop in Aarhus, Denmark. My talk is Monday in session 4 about: Oxygen Imaging of Hypoxic Pockets in Mouse Cortex. All about #braincapillaries #oxygen #pericytes #capillarystalling #microcirculation #neurovascularcoupling #imaging

Did you know that #neuronal #processes arrange perpendicular to #vascular direction around #penetratingarterioles and arterial end #capillaries? 🤔 I have speculated that this may enhance #neurovascularcoupling. Here I show examples in the #human #brain. 🧠 vb.bioscientifica.com/view/journal...

#Pericyte #TunnelingNanoTube in Retina😎

Inter-pericytic TNT connects capillaries of the same or different orders

Disrupted by ischemia

Opto-ablation of individual pericyte TNT🤠 compromises light-evoked #NeuroVascularCoupling

#Nature 2020
www.nature.com/articles/s41...