SARS-CoV-2 targets ribosomal RNA biogenesis Yerlici et al. report that SARS-CoV-2 Nsp1 localizes to the nucleolus and restrains human protein synthesis by thwarting the processing of ribosomal RNA molecules critical to ribosome manufacture. The...

SARS-CoV-2 targets
ribosomal RNA biogenesis

* SARS-CoV-2 Nsp1 interacting with precursor rRNA
* Nsp1 restrains nascent translation
* Repression of rRNA processing by Nsp1 is separable from mature ribosome inhibition

#Nsp1 #ProteinSynthesis #Ribosomes #18S #28S

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