Sepsis Sepsis is defined as a dysregulated host response to infection that leads to life-threatening organ dysfunction. The infectious insult triggers a dysr…

💥🆕“Sepsis”.The Lancet Seminar
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Corticosteroids and community-acquired pneumonia: Africa deserves an explanatory trial - Critical Care Critical Care -

🆕“Corticosteroids and community-acquired pneumonia: Africa deserves an explanatory trial”
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💥🆕“What Impacts Sepsis Outcomes in Low-Middle-Income Countries: Antibiotic Timing, Shock, or Supportive Care?”
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The Lancet Child & Adolescent Health journal cover for Volume 9, Issue 9, September 2025, with a child's colourful painting. Cover art is by Jhoan Mosquera Suarez, age 6 years. El Amor es la Mejor Medicina (Love is the best medicine) at University Hospital of Valle in Cali, Colombia.

Our September 2025 issue is now live with content on #dengue #chikungunya & #Zika virus, biomarkers for #sepsis, #ethnicity & #deprivation in #criticalcare outcomes, #RSV preF #vaccine rollout in #England & #Scotland & more

Read the full issue here👉 bit.ly/3FjByaz

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Read the full article here: www.thelancet.com/journals/lan...

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August 2025 cover image: a full moon over a town on a snowy evening. Cover image by Valeria Villareal, age 10 years

Our August 2025 issue is now live with content on #metabolic health in #China, #childhood #cancer medicines, #kidney outcomes in #hypertension, #ECMO use by social determinants of health & more

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Podcast Episode Hosted by Dr. Sergio Zanotti, CMO of Sound Critical Care, the Critical Matters podcast explores a broad range of topics related to intensive care medicine.

💥🆕“Management of Pneumonia in the ICU”
Critical Matters podcast I did with the great Dr Sergio Zanotti
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Cover image by Carmen Sofia Ambrosio, age 12 year: a ladybird among apple trees under a sunny sky

Our July 2025 issue is now live with content on #Caregiver concern and critical illness, co-occurrence of #Autism & #ADHD, #KangarooCare and infection, #Anaphylaxis observation duration & more

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How to approach a patient hospitalized for pneumonia who is not responding to treatment? - Intensive Care Medicine Pneumonia is a frequent cause of intensive care unit (ICU) admission and is the most common infection in ICU patients across all geographic regions. It takes 48-72h for most patients to respond to app...

💥🆕“How to approach a patient hospitalized for pneumonia who is not responding to treatment?”
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Guidelines without borders: the case for JAK inhibitors as the first-line immunomodulator COVID-19 treatment Identifying safe and effective immunomodulatory therapy for the treatment of infectious diseases has been an elusive pursuit for physician-scientists with mixed clinical results over the past few deca...

💥🆕“Guidelines without borders: the case for JAK inhibitors as the first-line immunomodulator COVID-19 treatment”
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Are All Cytokine Storms Born Equal? One of the most difficult medical challenges we have faced for decades is regarding the human host response to infectious and noninfectious insults. We are still lacking understanding on what constitu...

💥🆕“Are All Cytokine Storms Born Equal?”
Just out in JAMA – thanks to Sias Scherger and Anum Abbas!
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Early Antibiotic Initiation and Survival in... : Critical Care Medicine An abstract is unavailable.

🔥🆕“Early Antibiotic Initiation and Survival in Hospital-Acquired Pneumonia”
Just published – thanks to Subhadra Mandadi!
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Truly honored to be the inaugural speaker for the Center for Sepsis Epidemiology and Prevention Studies (SEPSIS) at the Harvard Pilgrim Health Care Institute.
www.populationmedicine.org/research/SEP...
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Subphenotypes and phenotypes to resolve sepsis heterogeneity: hype or hope? - Intensive Care Medicine Intensive Care Medicine -

🆕🔥“Subphenotypes and phenotypes to resolve sepsis heterogeneity: hype or hope?”
We just published this new article
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🆕🔥“Remdesivir-Associated Survival Outcomes Among Immunocompromised Patients Hospitalized for COVID-19: Real-world Evidence From the Omicron-Dominant Era"
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Sepsis: A Summary of the SEP-1 Quality Measure and Future Considerations

🆕💥“Sepsis: A Summary of the SEP-1 Quality Measure and Future Considerations"
Our new article was just published:
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Baricitinib: The Immunomodulator of Choice for Severe... : Critical Care Medicine An abstract is unavailable.

🆕💥“Baricitinib: The Immunomodulator of Choice for Severe COVID-19—The Verdict Is in”
Carlos Gomez and I just published this new article:
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🆕🔥"Is Antibiotic De-Escalation Safe and Beneficial to Patients with Sepsis?"
Our new article is out today:
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