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#DUNCAN T #MOORE
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#CLOSTRIDIUM #PERFRINGENS
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#clostridium #perfringens growth on blood agar plates is rapid, with colonies often detected within 12-16 hrs of inoculation. Colonies yellowish to gray opaque, 4-8mm irregular borders, double zone of hemolysis with inner zone of B-hemolysis surrounded by an outer zone of partial hemolysis

#Clostridial #myonecrosis, or gas gangrene, is most often caused by a traumatic injury
C #perfringens can be isolated from soil & is also one of most common clostridial species isolated from the intestinal tract of humans and other animals

#Clostridium #perfringens source bowel “mucositis” secondary to chemo. Massive hemolysis occurs in 2-15% pts w/ C. perfringens bacteremia
-alpha toxins (phospholipase C & sphingomyolinase) hydrolyze RBC membranes w/ loss of Hgb & resultant appearance as ‘ghost” cells #idsky