Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay AIM assays are thought to detect antigen (Ag)-specific T cell responses in an HLA- and cytokine-independent manner. Recent studies using AIM assays identified prominent Th17-like (CCR6+) CD4+ T cells ...

#Painstakingly #beautiful paper by Jenni Juno, these kind of investigations are rarely done! However, very important to measure #antigen #specific #Tcell #responses #accurately It is also interesting that @erictopol.bsky.social missed this! www.biorxiv.org/content/10.1...