The world of clinical trials is evolving from rigid to "Pragmatic & Adaptive." ECT proves that past data can save future lives.

Have you ever worked with External Controls or Synthetic Arms? Let’s discuss below! 👇

#PeerOnSky #ClinicalTrials #ExternalControlledTrials #RealWorldEvidence

Hi #ScienceSky people, back with #PeerOnSky series! After discussing reporting bias, let’s dive into a topic that’s currently reshaping regulatory landscapes and drug development: External Controlled Trials (ECT). Ever heard of "Synthetic Controls" or "Historical Controls"? Let’s break it down!

Frequency and reasons for outcome reporting bias in clinical trials: interviews with trialists Objectives To provide information on the frequency and reasons for outcome reporting bias in clinical trials. Design Trial protocols were compared with subsequent publication(s) to identify any discr...

Long time no see, #ScienceSky people! 👋 After a short hiatus, we're reliving the #PeerOnSky series.

A "silent" issue in clinical trials: Outcome Reporting Bias (ORB). Let's revisit a classic but vital paper by Smyth et al. (2010) that gets into the heads of trialists. www.bmj.com/content/342/...

Meta-analysis of individual participant data: rationale, conduct, and reporting The use of individual participant data instead of aggregate data in meta-analyses has many potential advantages, both statistically and clinically. Richard D Riley and colleagues describe the rational...

#PeerOnSky Article 2! "Meta-analysis of individual participant data: rationale, conduct, and reporting" by Riley et al. (2010). IPD boosts power for subgroups and adjusts for confounders. Read: doi.org/10.1136/bmj.... What challenges do you face in IPD meta-analyses? #OpenScience #MetaAnalysis

🔬 #PeerOnSky starts! “Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing” by Mello et al. (2018). They found participants value data sharing for science, but worry about privacy breaches. A 2018 perspective still relevant today! Does this reflect current views? #DataEthics

🎉 Hello all! Welcome to #PeerOnSky! It stands as 'Peer discussion on the Sky'. We will dive into cutting-edge research, sparking discussion on BlueSky using the articles discussed within our network. We’ll kick off with a 2018 gem on clinical trial data sharing. #OpenScience #Research #JournalClub