Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling

Systematic screening of a hemofiltrate-derived #PeptideLibrary identified that retinol-bound holo-RBP4 strongly reactivates latent #HIV1 in various T cell lines via activating the canonical NF-κB pathway, JAK/STAT5 & JNK signaling. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...