U01.02.034 Immunodeficiencies Phagocyte dysfunction Approach this clinical question by identifying key clues that point to an immune system defect. Focus on: Delayed umbilical cord separation Recurrent bacterial infections without pus formation Marked neutrophilia despite infection Absence of CD18 on leukocytes (via flow cytometry) These features together indicate a defect in leukocyte adhesion and migration. Analyze each option based on the underlying immune mechanism affected — phagocytosis, oxidative burst, or adhesion molecules — to select the most accurate diagnosis.

Learn about phagocyte dysfunction immunodeficiencies, including CGD, LAD, and Chediak-Higashi syndrome, their mechanisms, and clinical relevance. #Immunodeficiency #PhagocyteDysfunction #CGD #LAD #ChediakHigashi #Immunology #MedicalEducation #USMLE #Pathology #InnateImmunity #NeutrophilDefects