🔹 Calcitriol in IgA Nephropathy.

🔹 Finerenone Pooled Outcomes (FINE-HEART analysis).

🔹 Real-World Risk of Kidney Failure vs. Death in Diabetes.

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/EPO_Wf_nz2w

In this episode of Podocyte Talk, we delve into three important studies shaping the management of advanced chronic kidney disease (CKD):

🔹 Exercise Before Dialysis

🔹 Cost-Effectiveness of Low-Protein Diets

🔹 Spironolactone in CKD

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/NFMi6Ysez5w

In Episode 29 of Podocyte Talk, we cover three high-impact studies:

Measured GFR After Bariatric Surgery

Pregnancy and Long-Term Kidney Function in Chronic Kidney Disease

Dapagliflozin and Health-Related Quality of Life

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/yUfhuKXL_-s

In Episode 28 of Podocyte Talk, we discuss three clinically relevant studies advancing care in nephrology and transplant medicine:

Intradialytic Exercise Trial .

EVEREST Post-Hoc Analysis.

Transplant Infection Study (India).

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/LEh0boi4Ovc

🎙️New #PodocyteTalk!
GLP-1 RAs reduce death & boost transplant listing in dialysis.
Biomarkers predict CKD outcomes.
Sotradecol foam shrinks cysts in ADPKD/ADPLD.
📺 Watch & subscribe—85% of viewers still haven’t!
🔗 youtu.be/GKCeZsl1s2M
#nephrology #CKD

Podocyte Talk Episode 24:
– SGLT2i vs GLP-1RA in real-world CKD care
– Finerenone works regardless of early eGFR drop
– High-carb diets raise mortality in dialysis patients

#Nephrology #KidneyCare #Finerenone #SGLT2i #GLP1RA
#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/uMbtbhPYBPc

Simultaneous initiation of SGLT2i, RASi, ns-MRA, and GLP1-RAs presents a promising approach to mitigate the risk of CV events and the progression of kidney disease in patients with CKD.
#podocytetalk #Nephpearls #Nephrology #CKD

journals.lww.com/jasn/abstrac...

Finerenone reduced kidney and cardiovascular events in CKD and T2D patients, regardless of frailty. Benefits included lower albuminuria and slower eGFR decline, supporting its use even in frail individuals.

#podocytetalk #Nephpearls #Nephrology #CKD

journals.lww.com/cjasn/abstra...

Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists and Sodium/Glucose Cotransporter 2 Inhibitors in Preventing Chronic Kidney Failure and Mortality in Patients With Type 2 Diabetes... Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium/glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular, kidney, and survival outcomes in patients with type 2 diabetes; ...

Patients receiving SGLT2i demonstrated lower rates of progression to KRT compared to those receiving GLP1RA. These findings may inform the choice of these therapies in the setting of CKD and T2DM.

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

www.ajkd.org/article/S027...

Analysis of the prespecified FIDELITY pooled patient dataset examined the efficacy and safety of finerenone in patients with an acute change in estimated glomerular filtration rate. The efficacy and safety of finerenone (a non-steroidal mineralocorticoid receptor antagonist) versus placebo were assessed according to different changes in estimated glomerular filtration rate (eGFR)...

In patients with CKD and T2DM, finerenone reduced cardiovascular and kidney events regardless of whether eGFR rose or declined in the first month. Even with >10% acute eGFR drop, benefits were preserved.
#podocytetalk #CKD #Nephsky
www.kidney-international.org/article/S008...

In a diverse IgAN cohort, 36% reached kidney failure, major eGFR decline, or died within 2.7 years. Proteinuria ≥0.5 g/g strongly predicted poor outcomes, challenging past beliefs that <1 g/g is low risk.

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

academic.oup.com/ndt/advance-...

Kidney outcomes were poor in genetic nephrotic syndrome; in FSGS outcomes were strongly associated with proteinuria level. MCD patients had better proteinuria control than FSGS and had better outcomes at each proteinuria level.
#podocytetalk #Nephpearls #nephsky

journals.lww.com/jasn/abstrac...

Pre-treatment GFR slopes predict dapagliflozin response in IgA nephropathy Dapagliflozin exerts renoprotective effects in patients with IgA nephropathy (IgAN). However, the association between the pre-treatment estimated glomerular filtration rate (eGFR) slope and post-treat...

In IgA nephropathy, dapagliflozin slowed eGFR decline, especially in patients with faster pre-treatment loss. The pre-treatment eGFR slope predicted post-treatment benefit, suggesting value in guiding therapy.
#podocytetalk #CKD #GN #Nephsky

www.kireports.org/article/S246...

In Episode 23 of Podocyte Talk, we dive into three important new studies: use of finerenone in IgA nephropathy, incidence and outcomes of acute kidney injury in very old patients, and risk of UTIs with SGLT2 inhibitors

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

youtu.be/X5dh2G-FAuI

Podocyte Talk is now twice monthly! Each episode includes 2 multiple-choice questions—answer in the comments and test your nephrology knowledge!

In this episode, we explore three impactful studies in nephrology

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/C1MQgOdVdv4

✅ SGLT2 inhibitors in patients with advanced CKD
✅ Anti-nephrin antibodies as relapse predictors in MCD & FSGS
✅ Sacubitril/valsartan improves dialysis access flow in heart failure

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

youtu.be/YkNoV6CDmxU

Among low-risk patients undergoing PCI, contrast-associated AKI was rare, and withholding or continuing SGLT2 inhibitors had no impact on AKI risk or renal function. discontinuation in this setting may not be necessary.

journals.lww.com/kidney360/pa...
#Podocytetalk @asnpublications.bsky.social

This study highlights the negative impact of hypertension early after kidney transplantation and emphasizes the importance of effective treatment to improve long-term graft and patient survival.

www.kireports.org/article/S246...

#Podocytetalk #nephrology #CKD #Nephsky

BP targets post kidney transplant, SGLT2i use in angiography, and CGM insights in dialysis—all in Ep. 20 of Podocyte Talk. Tune in for key updates in nephrology! 🎧 #Nephrology #KidneyCare
#podocytetalk #Nephpearls #nephsky
youtu.be/fW2Ug1Sk9Rk

This week, we break down three major nephrology studies:
✅ Obinutuzumab’s role in lupus nephritis
✅ Best phosphate binders for dialysis patients
✅ Long-term effects of tolvaptan in ADPKD

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/86pdnfUKlsA

A JASN study links higher CKM stages to increased 15-year CV mortality (Stage 0: 5.5%, Stage 4: 15.2%). Stage 4 had a 9.6% higher risk. Early intervention is crucial.

journals.lww.com/jasn/pages/a...

#Podocytetalk #Nephrology #CKM

The long-term effect of tolvaptan treatment on kidney function and volume in patients with ADPKD AbstractBackground and hypothesis. The only therapy to ameliorate disease progression in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Tolvaptan slowed kidney function decline by 14%, reducing eGFR loss over time. However, it did not significantly impact total kidney volume (TKV) growth. Patients with higher osmolar intake showed a greater treatment response
#Podocytetalk #nephsky #nephrology
academic.oup.com/ndt/advance-...

In this episode of Podocyte Talk, we explore the impact of obesity on polycystic kidney disease progression, the predictive power of albuminuria in IgA nephropathy, and how tacrolimus metabolism affects kidney transplant outcomes

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/cFq0B8kr_ZU

Addition of a Loop Diuretic to Norepinephrine During Treatment of Hepatorenal Syndrome Type 1 Diuretics are commonly discontinued in patients with cirrhosis with acute kidney injury (AKI) because they are presumed to trigger hepatorenal syndrome type 1 (HRS-1). We hypothesized that if HRS-1 is...

In patients with HRS-1 who are adequately treated with norepinephrine and achieved an optimal MAP increment, addition of i.v. furosemide enhances diuresis without negatively affecting renal recovery.

www.kireports.org/article/S246...

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

High-intensity interval training significantly reduced the risk of rapid eGFR decline in older adults.

journals.lww.com/jasn/abstrac...

#podocytetalk #Nephpearls #CKD #nephsky

Can exercise slow kidney decline? How does Cardiovascular-Kidney-Metabolic (CKM) syndrome impact long-term survival? And can diuretics be safely used in hepatorenal syndrome?

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/2MgEtM6sh1w

Key Breakthroughs in Kidney Disease & Transplantation

"Exploring new insights into IgA nephropathy, kidney transplantation in lupus nephritis, and thrombotic microangiopathy post-transplant."

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

youtu.be/huUGTkIet04

No association was observed between aspirin use and risk of nonfatal atherosclerotic CVD or cardiovascular death in patients with CKD stages G3 and G4 without prior CVD. Aspirin use was associated with higher risk of major bleeding.

journals.lww.com/cjasn/abstra...

#podocytetalk #CKD #nephsky

In people with non–dialysis-dependent CKD, revascularization may be associated with lower all-cause mortality compared with medical management and may also lower the risk of cardiovascular events.

journals.lww.com/cjasn/pages/...

#podocytetalk #Nephpearls #CKD #nephsky

These findings support the use of sodium-glucose cotransporter-2 inhibitors in CKD, irrespective of frailty, multimorbidity, or polypharmacy.

CJASN 19(9):p 1119-1129, September 2024

#podocytetalk #Nephpearls #CKD #nephsky

journals.lww.com/cjasn/fullte...