March 10, 2026: NIH Pragmatic Trials Collaboratory to Host Workshop at Society for Clinical Trials 47th Annual Meeting - Rethinking Clinical Trials The NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the Society for Clinical Trials 47th Annual Meeting in Phoenix. Registration for the workshop is now open. The half-day […...

Register today for our preconference workshop, "Innovations in Embedded Pragmatic Clinical Trials," at the Society for Clinical Trials 47th Annual Meeting in Phoenix. #SCT2026 #pragmatictrials

Learn more ➡️ duke.is/pctnews20260...

March 9, 2026: AIM-CP Nurse Care Management Program Shows Promise for Rural Patients With Chronic Pain - Rethinking Clinical Trials A pilot study of the AIM-CP intervention showed that an integrated nurse care management model is a feasible and effective way to deliver nonpharmacological chronic pain treatment to patients in […]

A pilot study of AIM-CP, an NIH Collaboratory Trial, showed that an integrated nurse care management model is a feasible and effective way to deliver nonpharmacological chronic pain treatment to patients in rural communities. #pragmatictrials

Learn more ➡️ duke.is/pctnews20260...

November 25, 2025: Materials Now Available From NIH-Hosted Workshop, ‘Digging Into Dilemmas of Pragmatic Clinical Trials’ - Rethinking Clinical Trials Materials and videocast recordings are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Digging Into Dilemmas of Pragmatic Clinical Trials.“ The 2-day workshop, hosted by ...

Materials are now available from our NIH-hosted workshop, "Digging Into Dilemmas of #PragmaticTrials." Access slides and videos for all sessions, including a keynote by David Zaas, president of Atrium Health Wake Forest Baptist and professor at @wakeforest.bsky.social.

➡️ duke.is/pctnews20251...

A graphic showing the investigators of the AIM-CP, APA-SM, ARBOR-Telehealth, BeatPainU Utah, LungSMART, and RAMP trials

Today on National Rural Health Day, learn about our innovative pragmatic trials embedded in healthcare systems serving rural and remote populations:

• AIM-CP
• APA-SM
• ARBOR-Telehealth
• BeatPain Utah
• LungSMART
• RAMP

rethinkingclinicaltrials.org/demonstratio...

#PowerOfRural #PragmaticTrials

👏 Earlier today at ISPOR Europe, our CEO Denis Lacombe moderated the plenary session “Pragmatic Trials — Bridging Research and Real-World Care”.

🔗 Read more: www.eortc.org/blog/2025/11...

#ISPOR #ClinicalResearch #EORTC #CancerCare #PragmaticTrials

November 6, 2025: Enrollment Begins for APA-SM and iPATH Trials - Rethinking Clinical Trials Two of the newest NIH Collaboratory Trials have begun enrollment. Congratulations to the study teams from APA-SM and iPATH for reaching this important project milestone! APA-SM is enrolling patients i...

Kudos to 2 of the newest NIH Collaboratory Trials for beginning enrollment!

👂🏼 APA-SM
🏥 iPATH

Learn about these innovative #pragmatictrials embedded in healthcare systems: duke.is/pctnews20251....

REGISTER TODAY — Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effective Interventions — A workshop at the 18th Annual Conference on the Science of Dissemination and Implementation in Health — National Harbor, Maryland — December 14, 2025

Join experienced investigators from the NIH Pragmatic Trials Collaboratory to learn essentials of dissemination and implementation in #pragmatictrials in our full-day workshop at the @academyhealth.bsky.social 18th Annual D&I Conference. #DIScience25 #impsi

Register today! duke.is/pctnews20251...

November 3, 2025: IMPACT Collaboratory Seeks Letters of Intent for Demonstration Projects Grant Program - Rethinking Clinical Trials The NIA IMPACT Collaboratory announced a request for applications for its 2025 Demonstration Projects Grants Program. The program will fund up to 2 Demonstration Projects, each providing up to $800,00...

The IMPACT Collaboratory has announced a request for applications for its 2025 Demonstration Projects program. The awards will support full-scale #pragmatictrials of nonpharmacological interventions for people living with #dementia and their care partners.

Learn more ➡️ duke.is/pctnews20251...

🌎 Our vision: Transform #clinicalresearch by integrating high-quality research into routine patient care through the design and conduct of innovative #pragmatictrials to establish best practices and disseminate knowledge.

A graphic showing an overview of of the NIH Collaboratory program: Supports 37 large-scale, high-impact ePCTs; 16 NIH Institutes and Centers; >1400 clinical sites; >1.2 million patients; 49 US States and Puerto Rico.

🌱 Hello, Bluesky! We are the NIH Pragmatic Trials Collaboratory. Our community of researchers is advancing the design, conduct, and dissemination of pragmatic clinical trials by integrating high-quality #pragmatictrials into routine patient care.

Learn more at rethinkingclinicaltrials.org.

Embedded Clinical Research Embedded Clinical Research: Pragmatic Trials, Big Data, and Beyond Traditionally, clinical research has been kept separate from patient care because clinical r

📣 Do you conduct #Embedded research, including #PragmaticTrials, #ImplementationScience, or #LearningHealthSystems research?

⏰ The call for papers for our next *Special Issue* on embedded clinical research is live:

academic.oup.com/ptj/pages/cf...

Thread👇 on our #SysReview #MetaAnalysis with thoughts on which types of interventions could be important to evaluate in schools.

Link to paper:
www.frontiersin.org/journals/chi...

Had good discussion w #UniBern Summer Course participants about #PragmaticTrials and universal/targeted interventions.

Slide with Uni Dundee branding and a quote from Salsburg, D. (2001). The intent to treat. In The lady tasting tea: How statistics revolutionized science in the twentieth century (pp. 275–284). New York: Holt. The quote reads If we are interested in the overall results of a medical policy that would recommend the use of a given treatment, the physician has to be given the freedom to modify treatment as she sees fit. An analysis of a clinical trial, using Peto’s solution, would determine if it is good public policy to recommend a given treatment as a starting treatment. The application of the intent to treat method of analysis was proposed as a sensible one for large government-sponsored studies designed to determine good public policies.

Getting ready for my keynote on "Evidence-Based Professional Practice and Randomised Controlled Trials" where we will look a bit into #PragmaticTrials across #MentalHealth and #Education.

Pragmatic Trials eg. at #NIH
rethinkingclinicaltrials.org

Peto in quote, e.g.: pubmed.ncbi.nlm.nih.gov/795448/

📄We’re thrilled to announce a new EORTC publication in @thelancetoncol.bsky.social, led by EORTC Fellow Fábio Borges and CEO Denis Lacombe.

The paper highlights insights from a collaborative workshop on the role of #PragmaticTrials.

www.eortc.org/blog/2025/05...

www.youtube.com/watch?v=x3Tc...

Figure 1. One-word summary from attendees of the overall conference experience presented in a word cloud.

Gardener's Grove 2023 was an international conference of researchers, patients, and healthcare providers collaborating on the development of six #pragmatictrials aimed at improving #hemodialysis care. #Worldkidneyday
@cjkhd.bsky.social @csnscn.bsky.social

doi.org/10.1177/2054...

January 9, 2025: NIH Pragmatic Trials Collaboratory Will Hold Virtual Workshop on Emerging Issues in February - Rethinking Clinical Trials The NIH Pragmatic Trials Collaboratory will hold a virtual workshop on February 5 and 6, 2025, on “Digging Into Dilemmas of Pragmatic Clinical Trials.” Mike Cuffe, executive vice president and […]

Join @Collaboratory1 for a virtual workshop,” Digging into Dilemmas of Pragmatic Clinical Trials,” on February 5 and 6, 2025. Learn more: duke.is/2025-nih-vir... #pragmatictrials

What a fantastic session today— standing room only! Great #QCOR24 Methods Showdown ➡️ #pragmatictrials vs. #implementationscience vs. #communityengagedresearch.
🫀Word Cloud generated by our #QCOR24 at #AHA24 audience. Special thanks to Dr. Stacey Rosen #MadamePresident-Elect @ahascience.bsky.social

Are you ready for #QCOR24 at #AHA24? Join us bright and early at 8 am for an exciting program as we discuss #artificialintelligence #communityengagedresearch #healthequity #implementationscience #pragmatictrials #privateequity #OutcomesBeyondMACE #CardioSky #MedSky ##AHA100 @ahascience.bsky.social

Strengths, limitations and challenges of #pragmatictrials: https://www.nejm.org/doi/10.1056/NEJMra1510059

You are asking yourself how #logicmodel-s be used to frame & implement #evaluation-s using combinations of methods?

Have a look at this framework from educational research:


#RCT #pragmatictrials #EEF