Left: Probiotic strain abundance quantification in two probiotic intervention trials. Top left: Based on qPCR data, there was a significant enrichment in Akkermansia muciniphila and Bifidobacterium infantis probiotics in Validation Study A at Week 12 compared to Week 0. There was no enrichment of Clostridium beijerinckii, Clostridium butyricum, and Anaerobutyricum hallii probiotics. Bottom left: Based on shotgun metagenomic data, there was significant enrichment in Enterocloster bolteae, Flavonifractor plautii, Sellimonas intestinalis, and Clostridium symbiosum in Validation Study B at Week 12 compared to Week 0. Only E. bolteae and F. plautii showed notable enrichment above the relative abundance threshold of 0.005. Right: Switching from a low- to high-fiber diet in the Arivale cohort causes non-uniform shifts in MCMM-predicted butyrate production. Simulating a dietary shift from a low-fiber standard European diet (blue points) to a high-fiber diet (red points) results in a non-uniform increase in butyrate production across the study population (N = 1,786). Points from the same individual are connected by a horizontal gray line.
#Prebiotic & probiotic interventions can induce therapeutically relevant shifts in your #microbiome, but their effects vary. @gibbological.bsky.social &co show that metabolic models can predict #probiotic engraftment & shifts in SCFA production after intervention @plosbiology.org 🧪 plos.io/4asmMuV
