Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant - World Journal of Pediatrics Background MKRN3 gene loss-of-function mutations cause central precocious puberty (CPP), whereas its deletion in Prader–Willi syndrome (PWS) paradoxically leads to hypogonadism. The mechanistic basis ...

MKRN3 mutations spark early puberty, yet its loss in Prader-Willi syndrome delays it—new study traces this paradox to 18,000+ epigenetic switches, revealing how one gene drives opposite outcomes.

#Pediatrics #PrecociousPuberty #Prader-WilliSyndrome

link.springer.com/article/10.1...

Sorry Sally - The Government Feels 3rd Grade Menstruation Is Perfectly Fine But Sex Education Needs To Wait Until You're A HS Senior.

#PrecociousPuberty
#SexEducationPreventsAbortions
#GenitaliaObsessedParty

💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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💡 Spotlight on: Precocious Puberty 💡

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#PrecociousPuberty #GrowthCondition #GrowthConditions #SpotlightOn

Throughout 2025 we're running a monthly 'Spotlight on' series, shining a spotlight on different growth conditions each month.

Next week we'll be spotlighting Precocious puberty 💡

#PrecociousPuberty #GrowthCondition #GrowthConditions #SpotlightOn

Puberty blockers for young #TransPeople have been banned indefinitely in the UK with NI following suit stating a lack of evidence for their safety. Meanwhile, they've been used for over 40 years for non-Trans people with #PrecociousPuberty & other conditions & are not subject to the ban. 1/3