Prion-Like Brain Damage Can Occur Without Infectious Prions, Study Finds This is sobering.

Prion-Like Brain Damage Can Occur Without Infectious Prions, Study Finds #Science #HealthandMedicine #Neurology #Neuroscience #PrionResearch #BrainHealth

Random thought! Can we develop an AI like AlphaFold to predict and develop antibodies specifically target and binds to prions?

#AlphaFold #AntibodyDesign #PrionResearch #ProteinEngineering #DeepLearning #Biotech #DrugDiscovery

In vivo base editing extends lifespan of a humanized mouse model of prion disease - Nature Medicine An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion…

In vivo base editing via adeno-associated viruses reduced PrP and extended lifespan in prion disease mice 2.3x! Promising step for neurodegenerative therapy. #PrionResearch PMID:39810005, Nat Med 2025, @NatureMedicine

In vivo base editing using AAVs reduces PrP in mice, extending lifespan in a prion disease model. Exciting step in neurodegenerative therapy! #PrionResearch PMID:39810005, Nat Med 2025, @NatureMedicine https://buff.ly/3C9ZV97