Left: Lentivirus-mediated overexpression of full-length APP (holo-APP), sAPPα, or AICD in the cerebellar cortex of App−/− mice. Representative images showing co-expression of APP fragments/mCherry (red) and the PC marker calbindin (green) from coronal sections of the cerebellum. Scale bars: 100 µm (main); 40 µm (insets). Right: APP governs cerebellar motor function via Nav1.6 in Purkinje cells. APP deficiency impairs the surface distribution of Nav1.6 in Purkinje cells, leading to aberrant firing patterns, disrupted inhibitory output to the deep cerebellar nuclei, and culminating in motor coordination deficits.

The presence of aberrant forms of APP is linked to #AlzheimersDisease, but its loss leads to motor deficits. This study shows that #APP supports motor coordination by regulating Na+ channels in #PurkinjeCells, expanding our understanding of APP's role in the brain @plosbiology.org 🧪 plos.io/3M1WMwL

🚀 BlueSky trending hashtags (15m):

#booksky #birds #photography #art #nature #books #furryart #digitalart #poetry #furry #app #alzheimersdisease #purkinjecells #gamedev #canon

Left: Lentivirus-mediated overexpression of full-length APP (holo-APP), sAPPα, or AICD in the cerebellar cortex of App−/− mice. Representative images showing co-expression of APP fragments/mCherry (red) and the PC marker calbindin (green) from coronal sections of the cerebellum. Scale bars: 100 µm (main); 40 µm (insets). Right: APP governs cerebellar motor function via Nav1.6 in Purkinje cells. APP deficiency impairs the surface distribution of Nav1.6 in Purkinje cells, leading to aberrant firing patterns, disrupted inhibitory output to the deep cerebellar nuclei, and culminating in motor coordination deficits.

The presence of aberrant forms of APP is linked to #AlzheimersDisease, but its loss leads to motor deficits. This study shows that #APP supports motor coordination by regulating Na+ channels in #PurkinjeCells, expanding our understanding of APP's role in the brain @plosbiology.org 🧪 plos.io/3M1WMwL

Left: Lentivirus-mediated overexpression of full-length APP (holo-APP), sAPPα, or AICD in the cerebellar cortex of App−/− mice. Representative images showing co-expression of APP fragments/mCherry (red) and the PC marker calbindin (green) from coronal sections of the cerebellum. Scale bars: 100 µm (main); 40 µm (insets). Right: APP governs cerebellar motor function via Nav1.6 in Purkinje cells. APP deficiency impairs the surface distribution of Nav1.6 in Purkinje cells, leading to aberrant firing patterns, disrupted inhibitory output to the deep cerebellar nuclei, and culminating in motor coordination deficits.

The presence of aberrant forms of APP is linked to #AlzheimersDisease, but its loss leads to motor deficits. This study shows that #APP supports motor coordination by regulating Na+ channels in #PurkinjeCells, expanding our understanding of APP's role in the brain @plosbiology.org 🧪 plos.io/3M1WMwL

(6/8)
For #Cerebellum aficionados: yes, we looked at #PurkinjeCells (PCs).
Indirect PCs showed learning-related modulation, and interaction timescales with decoder units and M1 matched other cerebellar units.
#Electrophysiology #Neurocircuits

Trees arranged just like Purkinje cells in the cerebellum 😉

#cerebellum #chile 🧠🇨🇱

#purkinjecells & #cerebellargranulecells in #vinadelmar 🎨🧠🤓💚

#cerebrarte 😃👉🏼 nwnoggin.org/2023/07/08/l...

Marmosets produced dexterous tongue movements during recordings from the cerebellar vermis. Left: Subjects made saccades to visual targets and received a small amount of food as reward via one of two tubes placed obliquely to the mouth. In the task-relevant licks, they directed their tongue to the edge of the tube to harvest food near the tip (trajectories 2, 4), or inside the tube to harvest food that was deeper (trajectories 1, 5). In task irrelevant licks, they groomed their face (trajectory 3). Top right: Subjects chose to work for consecutive trials, making saccades and allowing the food to accumulate, then harvested their cache in bouts of licking. Bottom right: The authors employed silicon probes to record from lobule VI and VII of the vermis.

The cerebellum is known to control limb movements; does it also control the tongue? @rezashadmehr.bsky.social &co reveal how the #cerebellum controls the #tongue in marmosets, highlighting the role of #PurkinjeCells in terminating tongue movement at the target @plosbiology.org 🧪 plos.io/4lCK9Wj

Marmosets produced dexterous tongue movements during recordings from the cerebellar vermis. Left: Subjects made saccades to visual targets and received a small amount of food as reward via one of two tubes placed obliquely to the mouth. In the task-relevant licks, they directed their tongue to the edge of the tube to harvest food near the tip (trajectories 2, 4), or inside the tube to harvest food that was deeper (trajectories 1, 5). In task irrelevant licks, they groomed their face (trajectory 3). Top right: Subjects chose to work for consecutive trials, making saccades and allowing the food to accumulate, then harvested their cache in bouts of licking. Bottom right: The authors employed silicon probes to record from lobule VI and VII of the vermis.

The cerebellum is known to control limb movements; does it also control the tongue? @rezashadmehr.bsky.social &co reveal how the #cerebellum controls the #tongue in marmosets, highlighting the role of #PurkinjeCells in terminating tongue movement at the target @plosbiology.org 🧪 plos.io/4lCK9Wj

Marmosets produced dexterous tongue movements during recordings from the cerebellar vermis. Left: Subjects made saccades to visual targets and received a small amount of food as reward via one of two tubes placed obliquely to the mouth. In the task-relevant licks, they directed their tongue to the edge of the tube to harvest food near the tip (trajectories 2, 4), or inside the tube to harvest food that was deeper (trajectories 1, 5). In task irrelevant licks, they groomed their face (trajectory 3). Top right: Subjects chose to work for consecutive trials, making saccades and allowing the food to accumulate, then harvested their cache in bouts of licking. Bottom right: The authors employed silicon probes to record from lobule VI and VII of the vermis.

The cerebellum is known to control limb movements; does it also control the tongue? @rezashadmehr.bsky.social &co reveal how the #cerebellum controls the #tongue in marmosets, highlighting the role of #PurkinjeCells in terminating tongue movement at the target @plosbiology.org 🧪 plos.io/4lCK9Wj

Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

🚨 Our revised paper is now available in eLife! 🚨
We show that Purkinje cell orientation determines the polarity-dependent modulation of their firing rate during cerebellar tDCS in awake mice.

🧠✨ Check it out!

@elife.bsky.social
#tDCS #Cerebellum #PurkinjeCells #BrainStimulation #Neuroscience

#purkinjecells 🎨🧠💚🤓

#pipecleaners #makeart #brains #art #interdisciplinary #neuroscience #nwnoggin 🤗👉🏻 nwnoggin.org