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Here is a crystal structure of the 2'-dG-III riboswitch (PDB code: 9LKW)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #scivis #riboswitch #guanine #xray

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Small Molecule-Controlled Gene Expression: Design of Drug-like High-Affinity Modulators of a Custom-Made Riboswitch Riboswitches are regulatory RNA structures that modulate gene expression in response to a small molecule. Until now, most efforts to design ligand analogs were motivated by their potential antibiotic ...

Paper alert, some news on our #syntheticbiology activities. You can find out paper on the TPP #riboswitch activator at pubs.acs.org/doi/10.1021/.... And even better, you can order the compound for free on #boehringer 's #opnMe platform at www.opnme.com/molecules/tp....

#science

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1H, 13C, 15N and 31P chemical shift assignment of the first stem-loop Guanidine-II riboswitch from Escherichia coli - Biomolecular NMR Assignments A comprehensive understanding of RNA-based gene regulation is a fundamental aspect for the development of innovative therapeutic options in medicine and for a more targeted response to environmental p...

A new NMR assignment letter is online! Take a look at the secondary structure of the E.coli guanidine-II riboswitch!

Full text: doi.org/10.1007/s121...

#nmr #RNA #riboswitch #structure

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Looking forward to publishing new findings on #riboswitch #noncoding RNAs and other strange nucleic acids in the new year. I will try to post about the most interesting advances on Bluesky.

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