Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy - Nature Genetics The relationship between pathogenic germline variation, clonal hematopoiesis (CH) and risk of hematologic malignancy is explored in 731,835 individuals across 6 cohorts. Carriers of variants in certai...

Grateful for this important new study from @kellybolton.bsky.social & colleagues in Nature Genetics showing how germline variation, including in RUNX1, can shape CH and influence blood cancer risk. Research like this helps deepen our understanding of #RUNX1FPD.
doi.org/10.1038/s415...

Meet Jill & Arlo, a mother and son living with RUNX1-FPD. Jill has already raised $12,000 to help families like hers access clinical trials. It’s not too late for you to help too!

Givebutter: givebutter.com/rrpxout2025
GoFundMe: www.gofundme.com/charity/runx...

#XOutBloodCancer #RUNX1FPD

🚨 New Blog! 🚨

Sirolimus (rapamycin) is being studied for its anti-aging & immune-boosting effects. Could it help lower leukemia risk in RUNX1-FPD? A new clinical trial is testing its potential. Learn more! ⬇️

📖 www.runx1-fpd.org/runx1-pulse/...

#Sirolimus #Rapamycin #RUNX1FPD #ClinicalTrials

Shameless shoutout to the #RUNX1 Natural History Program of NHGRI as presented by Erica Bresciani. It’s my absolute pleasure to be a part of the program bringing together amazing patients and collaborators to study #RUNX1FPD #ASH24