#Trametinib treatment results in the feedback activation of multiple #ReceptorTyrosineKinases (RTKs) and subsequent treatment with #Anlotinib effectively mitigates KRAS-mutant #NSCLC progression through the MEK/RTK-IGFBP2-RTK signaling loop.

#STTT #OpenAccess: doi.org/10.1038/s413...