And BIG thanks to #RegSys track organizers @abardet.bsky.social A. Emad J. Welch R. Gordan @xiuweizhang.bsky.social R. Beekman @martamele.bsky.social @anniquec.bsky.social @shaunmahony.bsky.social @ferhatay.bsky.social and co-chairs @alemedinarivera.bsky.social and @themarcelschulz.bsky.social

What a fantastic #ISMBECCB2025 conference it has been, with an outstanding #RegSys @iscb-regsys.bsky.social COSI track!

Thanks, everyone, for submitting, attending, presenting, and organizing @iscb.bsky.social @eccb-europe.bsky.social

scooby - multimodal (rna/atac) profiles from dna at sc resolution. builds on borzoi. @lauradmartens.bsky.social #ISMBECCB2025 #regsys

Last talk at #regsys today is a keynote by Mafalda Dias about modelling sequence variation in Evolution with insights into diseases #ismbeccb2025

design biological sequences with cell type-specific activity using minimal number of edits and any ML model using github.com/jmschrei/led... by @jmschreiber91 #RegSys #ismbeccb2025

Laura Gunsalus talks about design of small native regulatory elements using #ML #ismbeccb2015 #regsys

Last talk in this #regsys session is Jishnu Das who talks about regulatory programs that determine B-cell fates #ismbeccb2025

Tatevik Jalatyan will talk about a new pipeline for estimating cell cycle phase from single cell data #ismbeccb2025 #regsys

Surag Nair talks about a general framework to combine different paradigms of DL genome models #ismbeccb2025 #regsys

Vitalii Kleshchenikow about a biophysical model for learning gene regulation from single cell data #ismbeccb2025 #regsys @oliverstegle.bsky.social

#regsys session is overflowing at #ismbeccb2025 consider to go to rooms 6 and 7 for video broadcast if full

Laura Rumpf talks about the MetaFR pipeline to learn gene regulation models from unpaired and paired scATAC and scRNA data #ismbeccb2025 #regsys #schulzlab @dzhk.de @sfb1531.bsky.social

Refreshed after lunch we start with Oluwatosin Oluwadare to introduce a new approach for single cell HiC analysis #ismbeccb2025 #regsys

inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences The accurate development, assessment, interpretation, and benchmarking of bioinformatics frameworks for analyzing transcriptional regulatory grammars rely on controlled simulations to validate the und...

And go to poster C-476 presented by Katalin Ferenc to learn more about inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences

doi.org/10.48550/arX...

#RegSys #ISMBECCB2025

Last speaker before lunch is Christophe Vroland to talk about confounders in Rna-Dna interaction data analysis #regsys #ismbeccb2025

Laura Hinojosa talks about TFs that regulate replication timing
#RegSys #ismbeccb2025 @ferhatay.bsky.social

Our own Damla @damlaob.bsky.social making a great presentation of the upcoming updates of JASPAR and UniBind with BPnet DL models at #RegSys @iscb-regsys.bsky.social #ISMBECCB2025
Chat with her at her poster D-485.

Next is
@damlaob to talk about putting new Deep learning models of TFs into #Jaspardb #RegSys #ismbeccb2025 @amathelier.bsky.social

First flash talk session starts with @aryankamal.bsky.social who represents his analysis about understanding transcriptional regulation in blood generation #regsys #ismbeccb2025

Second proceedings talk by an Panagiotis Alexiou about benchmarking methods for miRNA-target prediction #regsys #ismbeccb2025

First proceedings talk in #RegSys by Yijie Wang about GRN inference from single cell data

#RegSys is starting with the keynote from @verapancaldi.bsky.social who talks about the changes of chromatin structure and the epigenome in cancer patients #ismbeccb2025

🔬 Ever wonder how your immune system ages?
📊 We used single-cell multi-omics (RNA + ATAC) + bulk ATAC on PBMCs to build a cell-by-cell map of aging.
🧠 Find out which genes fade, which chromatin gates clos and why some immune systems age slower.
👉 Poster C-482 #RegSys
#ISMBECCB2025 #Aging #Multiomics

Today marks the start of the #RegSys @iscb-regsys.bsky.social track at ##ISMBECCB2025! Very much looking forward to listening to the exciting science that will be presented.

Join us in room 11BC today and tomorrow.

Join 4 #Schulzlab related talks at #ismbeccb2025 :
Wed #RegSys 14:20 , Laura Rumpf: Single-cell ATAC&RNA analysis,
Thu #iRNACOSI 8:40, Christina Kalk – Prediction of Split-ORFs
9:40 , Tim Warwick – Pipeline for DNA-RNA analysis
12:10 , Giulia Cantini – Transformer for miRNA-mRNA prediction

Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer Abstract. Cancer cells are highly plastic, favoring adaptation to changing conditions. Genes related to basic cellular processes evolved in ancient species

Wonderful sunny day in Liverpool for #ISMBECCB2025!
Marcelo Hurtado #TransMed talk on CellTFusion tomorrow 3:50, Hugo Chenel #NetBio poster (D-430) on GRNs. I will talk about our paper with Benoît Aliaga and Flavien Raynal in #RegSys on Wednesday. See you there!
academic.oup.com/nar/article/...

RegSys ISCB - International Society for Computational Biology

The #RegSys @iscb-regsys.bsky.social track is gonna be outstanding again this year with a great selection of talks and keynotes @verapancaldi.bsky.social, Mafalda Dias, Roser Vento-Tormo, and @lucapinello.bsky.social !

www.iscb.org/ismbeccb2025...

Excited to present our ongoing work @steglelab.bsky.social @sangerinstitute.bsky.social @bayraktarlab.bsky.social @mhaniffa.bsky.social @teichlab.bsky.social on whole embryo modeling of how TFs interact to drive specific CRE element activation in human organogenesis.
#RegSys
Wed 23 July, 14:40, 11BC

@vitaliikl.bsky.social will discuss how biophysical deep learning improves understanding of embryogenesis. He applied cell2state, his new method leveraging TF-motif interactions and biophysical constraints, on an unpublished multimodal sc and spatial atlas.
#RegSys
📅 July 23 | 🕑 14:40 | 📍 Room 11BC

I'm attending #ISMBECCB2025 in Liverpool, UK, July 20-24. Who else is going? Register by March 30 to save 10% on registration and enjoy risk-free cancellation. Don’t miss it!

We're looking forward to seeing you at the #RegSys track of #ISMBECCB2025!