USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...

New cool research alert!

Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA.

Read the full study: doi.org/10.1038/s414...

Another exciting research article from a member of the #RepliFate network!

The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.

Check out their findings here: doi.org/10.1016/j.ce...

DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication - Nature Communications The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing exces...

Just published!

Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication

VCP/p97 = checkpoint gatekeeper!

Read the full study: doi.org/10.1038/s414...

We’re excited to welcome artist Helen Pynor to @cbm-csic-uam.bsky.social as part of the #RepliFate artist-in-residence program! 🎨🧬

From June 24–July 5, she’ll explore how #DNAreplication shapes cell fate & cancer, bridging science & art with our researchers.

#SciArt #ArtInScience

🔬 Science Through an Artistic Lens🎨

🧬Led by Prof. Maria-Elena Torres-Padilla, the #RepliFate Artist-in-Residence Program brings #artists and #scientists together.

👉 t1p.de/j5pi8

@epihmgu.bsky.social @metorrespadilla.bsky.social @ec.europa.eu @annadumitriu.bsky.social @replifate.bsky.social