Brain-wide neuron quantification toolkit reveals strong sexual dimorphism in the evolution of fear memory Fear responses are functionally adaptive behaviors that are strengthened as memories. Indeed, detailed knowledge of the neural circuitry modulating fe…

Did you know that posttraumatic stress disorder is roughly twice as prevalent in women compared to men and that fear memories are stored in sex-biased networks, which may explain these differences? #sabv #ossd #sexdifferences #humanhealth #ptsd #fear #learningandmemory

Doctor measuring patient's blood pressure using a sphygmomanometer cuff on the arm.

New research in AJP-Renal shows obesity may eliminate a natural protection against salt-sensitive hypertension—especially in females—and the effect isn’t explained by sodium stored in the skin.

More: https://ow.ly/E3VX50Ys1SK APS Publications #ArticlesInPress #SABV #BloodPressure 🧪
📷: iStock

Sex dependency of subconscious visual perception - Biology of Sex Differences Males are more susceptible to neurodevelopmental cognitive deficits in their perception of visual information. Subliminally-presented visual stimuli might be subconsciously perceived and consequently ...

Did you know that a super quick flash of an image can still sway your decisions? Men seem to be influenced by these cues even more than women! #sabv #ossd #sexdifferences #humanhealth link.springer.com/article/10.1...

Woman with ponytail touching her sore neck highlighted in red against a brick wall background.

OUCH! That stubbed toe sure hurts, but your gender may determine how much.

Research shows differences in cellular makeup can make pain last longer for women than men. Check out Newsweek for more: https://ow.ly/hZ7s50YmIts #ISpyPhysiology #SABV #PainResearch #CellularBiology 🧪
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Annual Meeting

More reasons to join us in #Hawaii??

Showcase your work at the upcoming #OSSD2026 20th annual meeting and you can submit your work to a special collection in Biology of Sex Differences!

Meeting info: www.ossdweb.org/ossd-annual-...

#OSSD #SABV

Weekend plans? #OSSD members-Don’t forget to vote🗳️!

Take a moment to cast your vote for the next #OSSD Council members! Your vote helps shape the future of the society and the field of sex differences research #SABV.

Check your email for voting details!

⏰DEADLINE TODAY! Connect with colleagues, showcase your newest work, and join the sex differences research community in beautiful #Hawaii for #OSSD2026!

#OSSD #SABV

Sex-specific neural responses to smartphone cues in young adults - Biology of Sex Differences Problematic smartphone use has been associated with altered reward and executive control network activity, yet potential sex differences in the underlying neural mechanisms remain insufficiently under...

Did you know? 📱 When seeing smartphone cues in an MRI, young men show stronger activation in attention and control brain networks: The more activated, the higher their craving. Whereas women show a different pattern: Brain activity decreasing as problematic use increases. #sabv #ossd

Portrait of Tracy L. Bale, PhD, keynote speaker for APS 2026, specializing in women's health research at University of Colorado Anschutz Medical Campus.

Kick off #APS2026 right with the opening keynote April 23 from Tracy Bale!

She studies the role of stress in neuropsychiatric disease and the sex differences that underlie disease vulnerability in humans.

Learn more: https://ow.ly/eakB50YoT8R #WeArePhysiology #SABV 🧪
📷: iStock

📽️ Lastly, Dr Karp tackles the complexity of sex across the animal kingdom and the impact of the language we use when communicating about sex as a biological variable.
#SABV
www.youtube.com/watch?v=WceZ...

Navigating the paradigm shift of sex inclusive preclinical research and lessons learnt - Communications Biology As progress is made in sex-inclusive preclinical research, the author highlights areas of research practice where significant development has been achieved & where more change is needed towards co...

🧵The way we think about and carry out sex-inclusive preclinical research is developing. In 4 short video “explainers”, Dr Natasha Karp, in collaboration with #MRC, highlights 4 key considerations, which were earlier explored by her in a Comment @CommsBio.
@ukri.org #SABV
doi.org/10.1038/s420...

Starting now on zoom! Register to access the zoom link.

Can't make it? A recording will be available at: www.ossdweb.org/ossd-connected

Stay tuned for the next OSSD Connected Seminar!

#OSSD #SABV

Senior woman in a pink shirt lifting a kettlebell during a workout session indoors.

New research: Eccentric “overload” training—adding extra load as a muscle lengthens—built more force-producing segments than conventional resistance training.

Females saw the largest gains.

Read more from AJP-Cell: https://ow.ly/KPyu50YkyyN APS Publications #ArticlesInPress #SABV
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Sex-specific gonadal transcriptome during early development of Siberian sturgeon - Biology of Sex Differences Background Sex determination and differentiation are complex processes shaped by a wide variety of molecular factors. In contrast to teleost species, many aspects of these processes remain poorly unde...

Did you know? 🐟 By just 2.5 months old, Siberian sturgeon show sex-specific gene activity in their gonads: Females light up estrogen-response genes, while males activate new testis candidates, even without male hormone genes in play! #sabv #ossd #sexdifferences link.springer.com/article/10.1...

Genomic characterization of Sabiá virus in Brazil, 2019–2020: Implications for diagnostics, virus evolution, and receptor binding Author summary Sabiá virus (SABV), also known as Brazilian mammarenavirus, causes severe hemorrhagic fever, with mortality rates among New World arenaviruses averaging around 30%. Over the past 40 yea...

🧪 Two patients suspected of having severe yellow fever were admitted with acute hemorrhagic syndrome and neurological alterations; both cases were fatal. Sabiá virus #SABV, a New World #arenavirus, was identified as causative pathogen @plos.org dx.plos.org/10.1371/jour...

Close-up of a finger pressing a wooden block with a female gender symbol next to a blue block with a male symbol on a textured surface.

Biological context matters.

Without a particular gene that helps make insulin, only females showed worse blood sugar control on a high-fat diet.

Estrogen seemed to flip the switch.

Details at AJP-Endo: https://ow.ly/O5Nu50YcAkA APS Publications #ArticlesInPress #SABV 🧪
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Women in Science: How Far We’ve Come and Where We Still Need to Go - I Spy Physiology Blog The International Day of Women and Girls in Science is on February 11. While women have long been hidden from the scientific history books, influential figures—Hedy Lamarr, Katherine Johnson and Rosalind Franklin to name a few—are becoming more and more celebrated in mainstream media for their work. Yet, women and girls are still not an … Continue reading Women in Science: How Far We’ve Come and Where We Still Need to Go

Today, we celebrate #WomenAndGirlsInScience. Studies are including more women, but there’s still work to do. Learn why #SABV in biomedical research matters for better science and care in this vintage #ISpyPhysiology blog post: https://ow.ly/fl8i50Y8flZ #GirlsInSTEM 🧪

Throwing like a girl: a critique of past approaches and an illustrated proposal for a path forward - Biology of Sex Differences Background The phrase “Throwing like a girl” persists in popular culture and in scientific research as a trope about biological differences between males and females. In this review/theoretical paper ...

Did you know? “Throwing like a girl” isn’t biology. Fausto-Sterling found that infants who start ball play earlier (often boys) practice from stable positions and throw farther sooner. Timing and practice, not sex, shape throwing skill. #SABV #OSSD #sexdifferences
link.springer.com/article/10.1...

Sex differences in noradrenergic regulation of the medial prefrontal cortex in mice - Biology of Sex Differences Background Norepinephrine (noradrenaline; NE) is a stress signal released from the locus coeruleus (LC) into the prefrontal cortex (PFC) to govern arousal, attention, and cognition. The LC is sexually...

Did you know female brains have stronger norepinephrine projections from locus coeruleus to prefrontal cortex? BUT prefrontal neurons are less sensitive to signaling than in males! This study found sex differences in this stress and decision-making circuitry. #sabv #ossd #sexdifferences #humanhealth

The Question That Changed Basic Research: "What Happened to the Women?" 🗣 Dr. Teresa Woodruff recounts the simple, yet profound, question she asked early in her career. 

#WomenInSTEM #SciencePolicy #HealthEquity #SSR #SABV

📣 Save the date:

The 3rd SABV Biennial Symposium, organized by Dr. Ivana Jarić, will take place at the University of Zurich on 23–24 June 2026.

The meeting will focus on why and how sex-inclusive research strengthens biomedical science and translational outcomes.

#SABV #SABVinAction #EUSABV

Early research hints at why women experience more severe gut pain than men do A mouse study suggests estrogen may increase gut pain by activating specific cells, offering hints to why IBS is more common in women than in men.

Women often have worse gut pain than men and are diagnosed with #IBS twice as much. Research hints estrogen may make gut nerves more sensitive. Read more in Live Science: https://ow.ly/iiKr50Y3XCt #ISpyPhysiology #SABV 🧪

Establishment of sex-specific liver transcriptomes and H3K9me3 profiles during sexual maturity: the impact of maternal obesity - Biology of Sex Differences Background The escalating prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to rising obesity rates. Maternal obesity (MO) is associated with increased s...

A mother's diet can leave lasting epigenetic fingerprints on her offspring's liver, altering how genes are expressed, long after the young eat healthy again. These changes can disrupt metabolism sex-specifically, potentially raising lifelong risk for fatty liver disease. #sabv #ossd #sexdifferences

Impact of continuous testosterone exposure on reproductive physiology, activity, and pain-related behavior in young adult female rats Testosterone may reduce pain in cisgender women and transgender men. Rodents can provide a useful model for investigating physiological effects of hor…

Giving female rats testosterone at male-like levels helped them bounce back faster after surgery, but it didn't actually make them experience less pain. Testosterone boosted recovery, not pain resistance! #sabv #ossd #sexdifferences #humanhealth www.sciencedirect.com/science/arti...

This just in: Deadline to submit poster abstracts and for travel award consideration has been extended to tomorrow, January 20, 2026! Submit your abstracts and join us for the 2026 Annual OSSD Meeting at the Hilton Waikoloa Village in Kona, Hawaii, May 12-16, 2026! More info below:
#OSSD #SABV

Biological sex matters in brain aging Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …

Did you know that every cell in your body has a biological sex? Exploring how male and female cells age differently is opening the door to new ways of diagnosing and treating brain aging. #sabv #ossd #sexdifferences #humanhealth

www.sciencedirect.com/science/arti...

But he also said something about “considering non-animal model” approaches which sounds a bit like #SABV to my ear. Volkow talking about accelerating translation with nonanimal approves ….hmmm.

Sexual dimorphism in the serum metabolome following acute exhaustive exercise - Biology of Sex Differences Background Sex differences in exercise metabolism have been recognized for decades, but the molecular metabolic landscape in which men and women reach standardized physiological exhaustion criteria re...

Did you know even when men and women push themselves to the exact same level of exhaustion, their bodies use unique molecular strategies to process fat? Scientists found several blood molecules that move in opposite directions between sexes! #sabv #ossd #sexdifferences #humanhealth

Soldiers in full combat gear walking through a rugged landscape at sunrise with mountains in the background.

December's "best of the best" from APS Publications are free to read:
➡️EVs track stress in military mountain training.
➡️Exercise resets body clock differently by sex.
➡️Specialized brain cells remodel for seasonal changes.
Read more: https://ow.ly/GTMV50XAfPH #APSselect #SABV 🧪
📷: iStock

Woman in green shirt reading prescription bottle label in modern kitchen with glass of water on counter.

If you’ve tried on unisex clothing, you know the fit is rarely perfect. A one-size-fits-all approach with meds can leave women open to adverse drug reactions. More from APS member Heidi Creed on the #ISpyPhysiology blog: https://ow.ly/NpHI50XBtLj #SABV #WomensHealthResearch 🧪
📷: iStock