💻 Using the #fragment #screening analysis from our #FRAGSYS pipeline, combined with high quality #Google #Deepmind's #AlphaFold #Multimer (ColabFold) models of the #SACK1G dimer, we identified and #prioritised 13 #residues in a binding site of interest as likely #functionally #relevant.

🚀 In this study, @gjbarton.bsky.social and I collaborated with the group of Gopal #Sapkota at the @mrcppu.bsky.social at the #SLS of the University of Dundee to shed some light into the loss of interaction between #SACK1G and #CK1α, which underlies the pathogenesis of Palmoplantar Keratoderma (PPK).

🚀 For this study, @gjbarton.bsky.social and I teamed up with the group of Gopal #Sapkota at @mrcppu.bsky.social in the School of Life Sciences of Dundee Uni to shed some light in the loss of interaction between #SACK1G and #CK1α, which underlies the pathogenesis of #Palmoplantar #Keratoderma (PPK).