SPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case Study Genetic mutations often result in antimicrobial resistance. Early identification of emerging resistance due to genetic mutations often relies on multiple co-existing pathways of indirect evidence. The...

💥New paper from #MAGICevidence community: #SPICEGRADE explores how to assess certainty of the evidence when causal inference relies on chains ⛓️ of indirect evidence.
An important step as evidence ecosystems become more complex:
www.jclinepi.com/article/S089...