#SPINA_Thyr predicts the prognosis of #Takotsubo syndrome. Among all predictors, #SPINA-GD showed the most significant difference.

🧪 🩺 #MedSky @medsky.social #Endocrinology

#SPINA_Thyr helps in decision-making to implement this algorithm.

#SPINA_Thyr and #SPINA_Carb, two implementations of the structure parameter inference approach (SPINA), provide evidence-based improved methods for diagnosis and endotyping of endocrine diseases. Now, thoroughly tested apps for Mac and Windows are available for free download.

spina.sf.net

Screenshot of SPINA Carb Release Candidate 1 for macOS

After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing.

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...

More and more studies reveal parameters of #SPINA_Thyr to be influenced by #xenobiotics and other #endocrine #disruptors. Calculating functional biomarkers of #thyroid #homeostasis may contribute to increased sensitivity in environmental toxicology. 🧪🩺

#SPINA_GD #pollutants #toxicants #environment

Screenshot of SPINA Thyr 4.2.1 on macOS Ventura 13.6.4

#SPINA_Thyr 4.2.1 released. This new version fixes several minor bugs. It is compatible with Windows (32 and 64 bits), macOS (Intel and Apple Silicon) and several Unix and Linux variants. spina.sourceforge.net doi.org/10.5281/zeno... doi.org/10.5281/zeno... 🩺 🧪

Pearson correlation between paraben and thyroid hormones and IGF-1

Adjusted regression coefficient and 95% CI for change in serum thyroid and growth hormones in relation to unit-increased in Ln-parabens (ng/mL) in Taiwanese minors (N = 75)

Regression coefficients (95% confidence intervals) for a change in Jostel’s TSHI, sTSHI, SPINA-GD and SPINA-GT associated with quartiles of four urinary parabens concentrations in minors.

🧪 #SPINA_Thyr may be useful for monitoring of #endocrine disruptors. #SPINA_GD correlates to paraben excretion, and #SPINA-GT is modified due to exposure to butylparaben. doi.org/10.1007/s113... pubmed.ncbi.nlm.nih.gov/38038926/