📗 New in Autoimmunity from Taylor & Francis Research "The shared mechanisms and potential diagnostic markers for IgA nephropathy and celiac disease" with Y.Becker, P.Schroder, H.Haller & MDI Bio Lab Visiting Scientist Guibao Ke.

🧪 #ScientificResearchPublishing

📕 New in the Society of Toxicology journal Toxicological Sciences, "Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction" with Iain Drummond & team.

🧪 🐟🎸 #ScientificResearchPublishing #NephSky #RenalSky

https://doi.org/10.1093/toxsci/kfag007

New in @dev-journal.bsky.social, “Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney” with Caramai Kamei, Iain Drummond & team.

🧪 🐟🎸 #ScientificResearchPublishing

doi.org/10.1242/dev....

📗 New paper in PLOS Genetics, "Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression" from Romain Menard, Romain Madelaine & team.

https://doi.org/10.1371/journal.pgen.1012019

🧪 🐟🎸 #ScientificResearchPublishing

📚 New paper published in Kidney International, "Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction" by Anastasia Paulmann, Hermann Haller & team: https://doi.org/10.1016/j.kint.2025.12.011

#NephSky #RenalSky #ScientificResearchPublishing 🧪 👩‍🔬

📗 New in Physiological Reports from @wiley.com — "Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury in mice" with Dr. Hermann Haller.

https://doi.org/10.14814/phy2.70642

#researchmatters 🧪 🤝 #ScientificResearchPublishing

Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity Monocyte heterogeneity and plasticity create a spectrum of phagocytes essential for innate immune functions, which is partially regulated by Notch sig…

New from iScience, "Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity" with MDI Bio Lab affiliated Frauline Nicole Schroth and Hermann Haller.

#ScientificResearchPublishing #ResearchPublishing 🧪 🤝 🍎

Kynurenine Pathway Dysregulation Impairs Podocyte Morphology and Bioenergetics In Vitro and Leads to Glomerular Dysfunction The enzymes of the kynurenine pathway participate in the catabolism of TRP, where they generate metabolites known as kynurenines, which are considered biologically active. Using a transgenic zebrafis....

New research article in @faseborg.bsky.social, "Kynurenine Pathway Dysregulation Impairs Podocyte Morphology and Bioenergetics In Vitro and Leads to Glomerular Dysfunction" with Patricia Schroder, Lynne Staggs, and Hermann Haller.

#ScientificResearchPublishing 🧪 🤝 #SciEd

JCI Insight - Cytoskeleton-associated protein 4 affects podocyte cytoskeleton dynamics in diabetic kidney disease 1Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

📗 New paper in @jclinical-invest.bsky.social, "Cytoskeleton-associated protein 4 affects podocyte cytoskeleton dynamics in diabetic kidney disease" with MDI Bio Lab Visiting Scientist Mario Schiffer, University Hospital Erlangen.

#standwithscience #researchmatters 🧪 🤝 #ScientificResearchPublishing

Effect of Cu(ATSM) on the expression and activity of ABC export proteins in killifish (Fundulus heteroclitus) kidney tubules ABC transporters are important for excretion of xenobiotics and metabolites into urine. They are sensitive to metallic pollutants like cadmium, mercur…

We are proud to announce that two of MDI Bio Lab's visiting scientists were recently published by @elsevierconnect.bsky.social in Environmental Toxicology and Pharmacology.

Congratulations to @uniheidelberg.bsky.social scientists Gert Fricker and Lisa Kraus.

🧪 🤝 #ScientificResearchPublishing

A new preprint is out from @biorxiv-devbio.bsky.social with research from MDI Biological Laboratory's
@murawalalab.bsky.social.

🧪 🤝 #ScientificResearchPublishing #SciencePublishing #ResearchPublishing #AcademicPublishing #regeneration

The small molecule ML233 is a direct inhibitor of tyrosinase function - Communications Biology In vivo, in vitro and in silico validation of the direct inhibition of Tyrosinase activity by the ML233 small molecule reveal a therapeutic candidate for skin disorders.

A new publication is now out from @commsbio.bsky.social:
"The small molecule ML233 is a direct inhibitor of tyrosinase function" by R.Menard, A.Baanannou, C.Halluin, D.Morse, S.Kuhn, @jhgrabermdibl.bsky.social, J.Strickland & R.Madelaine.

🧪 🤝 🐟🎸 👩‍🔬 #ScientificResearchPublishing #ResearchPublishing

colorful graph

🔎 A new publication in Cells & Development from @elsevierconnect.bsky.social, "The evolutionary origin and mechanism of chordate tail regeneration. An ancient tale?" from @murawalalab.bsky.social:

doi.org/10.1016/j.cd...

🧪🤝 #ScientificResearchPublishing #ResearchPublishing #AcademicPublishing

woman in laboratory

Researchers Hyemin Min and @dustinupdike.bsky.social show that #celegans could lead to breakthroughs in understanding pregnancy complications & improving maternal health in a recent Development paper (@biologists.bsky.social) : 🧪🤝 #reprosky #ScientificResearchPublishing

mdibl.org/what-a-tiny-...

Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition - Leukemia Leukemia - Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition

📕 New in Leukemia from Springer Nature Group, "Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition" with Eric Wang: www.nature.com/articles/s41... #jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis A pan-cancer repository of >1,000 patient-derived xenograft hematoxylin and eosin–stained images will facilitate cancer biology investigations through histopathological analysis and contributes import...

📕 From AACR Journals: "A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis" with Brian White, Carol Bult, Jeffrey Chuang and team: aacrjournals.org/cancerres/ar... #jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing

Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice - GeroScience Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan prediction could accelerate these studies and reduce the need for veterinary interventi...

📗 New in GeroScience from Springer Nature Group, "Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice" with Alison Lu: link.springer.com/article/10.1... #jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing

📔 New in Advanced Functional Materials from Wily, "Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model" with Mikail Dogan & Derya Unutmaz: onlinelibrary.wiley.com/doi/10.1002/...
#jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing

Speech and language classification in the human phenotype ontology - European Journal of Human Genetics European Journal of Human Genetics - Speech and language classification in the human phenotype ontology

📓 New in the European Journal of Human Genetics from Nature Portfolio, "Speech and language classification in the human phenotype ontology" with Ben Coleman & Peter Robinson: www.nature.com/articles/s41...
#jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing

Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells Humanized mice, defined as mice with human immune systems, have become an emerging model to study human hematopoiesis, infectious disease, and cancer.…

📗 New in STAR Protocols from Cell Press, "Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells" by Chun Yu, Rick Maser, Florentina Marches & Karolina Palucka: www.sciencedirect.com/science/arti... #jaxresearch🧪🤝🖥️ 🧬 #scientificresearchpublishing

Active Molecular Network Discovery Links Lifestyle Variables to Breast Cancer in the Long Island Breast Cancer Study Project A healthy lifestyle has been associated with decreased risk of developing breast cancer. Using untargeted metabolomics profiling, which provides unbiased information regarding lifestyle choices such a...

📕 New in Environment & Health from ACS Publications, "Active Molecular Network Discovery Links Lifestyle Variables to Breast Cancer in the Long Island Breast Cancer Study Project" with Miao Yu: pubs.acs.org/doi/10.1021/... #jaxresearch🧪🤝🖥️ 🧬 #scientificresearchpublishing

scientific image showing phenotype processing

📘 New in Redox Biology, "Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics" with Susan McClatchy & Gary Churchill:

doi.org/10.1016/j.re...

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing

CDK4/6 inhibition enhances T-cell immunotherapy on hepatocellular carcinoma cells by rejuvenating immunogenicity - Cancer Cell International Hepatocellular carcinoma (HCC) poses a significant clinical challenge, necessitating the integration of immunotherapeutic approaches. Palbociclib, a selective CDK4/6 inhibitor, has demonstrated promis...

📔 New in Cancer Cell International from BMC, "CDK4/6 inhibition enhances T-cell immunotherapy on hepatocellular carcinoma cells by rejuvenating immunogenicity" with Xiurong Cai: doi.org/10.1186/s129...

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #immunosky #OncoSky #ScientificResearchPublishing

Study reveals potential therapeutic role of sodium valerate in reducing binge drinking Researchers from JAX and UConn Health uncover gut-brain connection that may mediate alcohol consumption in mouse model.

A recent study published in Microbiome Journal from Jason Bubier and colleagues identifies a microbiome metabolite-based novel treatment that can reduce excessive alcohol drinking — sodium valerate: 🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing

www.jax.org/news-and-ins...

Association of post-COVID phenotypic manifestations with new-onset psychiatric disease - Translational Psychiatry Translational Psychiatry - Association of post-COVID phenotypic manifestations with new-onset psychiatric disease

📘 New in Translational Psychiatry from @natureportfolio.bsky.social, "Association of post-COVID phenotypic manifestations with new-onset psychiatric disease" with Ben Coleman, Hannah Blau & Peter Robinson: bit.ly/3Xo7XU1

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing

Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations - Cell Death & Disease Cell Death & Disease - Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations

📗 New in Cell Death and Disease from Springer Nature Group, "Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations" with Elizabeth Werren:
bit.ly/4aGWAJR

🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing

Study explores impact of workplace genetic testing on employee health behaviors JAX and University of Michigan reveal how genetic testing provided by the workplace impacts employee health choices and behaviors

In a new Genetics in Medicine study, JAX researchers, led by Charles Lee, and scientists from the University of Michigan, reveal how genetic testing, provided by the workplace, can impact employee health choices and behaviors:
www.jax.org/news-and-ins...

#ScientificResearchPublishing 🧪🤝🖥️ 🧬 ⑂

3-Hydroxyanthranilic Acid Delays Paralysis in Caenorhabditis elegans Models of Amyloid-Beta and Polyglutamine Proteotoxicity Age is the primary risk factor for neurodegenerative diseases such as Alzheimer’s and Huntington’s disease. Alzheimer’s disease is the most common form of dementia and a leading cause of death in the ...

📗 New in Biomolecules MDPI, "3-Hydroxyanthranilic Acid Delays Paralysis in Caenorhabditis elegans Models of Amyloid-Beta and Polyglutamine Proteotoxicity" with Caroline Corban, Grant Backer, Susan Sheehan & Ron Korstanje:
bit.ly/3X1z8Uq

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing

Mitochondrial DNA release and sensing in innate immune responses Abstract. Mitochondria are pleiotropic organelles central to an array of cellular pathways including metabolism, signal transduction, and programmed cell d

📘 New Review in Human Molecular Genetics, "Mitochondrial DNA release and sensing in innate immune responses" with Jordyn Van Portfliet & Phillip West:

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #immunosky #ScientificResearchPublishing

bit.ly/4bYeZD9

Reinvigorating exhausted immune cells reveals potential therapy target for cancer Reenergizing exhausted T cells, with help from a rare immune cell known as a basophil, can kickstart the immune system into fighting cancer.

A new paper from Lucas Chang in Cancer Immunology Research, shows how reenergizing exhausted T cells, with help from a rare immune cell known as a basophil, can kickstart the immune system into fighting cancer:

🧪🤝🖥️ 🧬 ⑂ #CanSky #OncoSky #immunosky #ScientificResearchPublishing

bit.ly/4aVh6q5