Top: Snapshots of the representative escape responses of WT (upper) and NaVDKO (lower) zebrafish at 4 dpf in normal water. Images were captured every 2 ms. Scale bar: 1 mm. Middle: Representative Ca2+ imaging of WT myocytes at 3 dpf embryos. Numbers below the images indicate time from the beginning of the recording. Fluorescent intensity is shown in color. Bottom: Ca2+ imaging of WT myocytes at 5 dpf in the presence of 1 μM TTX.

Are action potentials in vertebrate muscle essential for contraction? This study of #zebrafish lacking #SodiumChannel NaV1.4 reveals that NaVs are dispensable for #muscle contraction, so the need for muscle #ActionPotentials can vary between vertebrates @plosbiology.org 🧪 plos.io/42EXQwx

Top: Snapshots of the representative escape responses of WT (upper) and NaVDKO (lower) zebrafish at 4 dpf in normal water. Images were captured every 2 ms. Scale bar: 1 mm. Middle: Representative Ca2+ imaging of WT myocytes at 3 dpf embryos. Numbers below the images indicate time from the beginning of the recording. Fluorescent intensity is shown in color. Bottom: Ca2+ imaging of WT myocytes at 5 dpf in the presence of 1 μM TTX.

Are action potentials in vertebrate muscle essential for contraction? This study of #zebrafish lacking #SodiumChannel NaV1.4 reveals that NaVs are dispensable for #muscle contraction, so the need for muscle #ActionPotentials can vary between vertebrates @plosbiology.org 🧪 plos.io/42EXQwx

Top: Snapshots of the representative escape responses of WT (upper) and NaVDKO (lower) zebrafish at 4 dpf in normal water. Images were captured every 2 ms. Scale bar: 1 mm. Middle: Representative Ca2+ imaging of WT myocytes at 3 dpf embryos. Numbers below the images indicate time from the beginning of the recording. Fluorescent intensity is shown in color. Bottom: Ca2+ imaging of WT myocytes at 5 dpf in the presence of 1 μM TTX.

Are action potentials in vertebrate muscle essential for contraction? This study of #zebrafish lacking #SodiumChannel NaV1.4 reveals that NaVs are dispensable for #muscle contraction, so the need for muscle #ActionPotentials can vary between vertebrates @plosbiology.org 🧪 plos.io/42EXQwx

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

🎄In just one week, Prof Ben Corry @corrylab.bsky.social will give a seminar on #sodiumchannel inactivation and inhibition when using #molecularsimulations 💻🧪

Join us on the 17th of December:
sodiumchannelseminars.org/Program-2024...

Carol Ann Remme, PhD is presenting "Pharmacological and genetic approach to enhance cardiac sodium channel function"

sodiumchannelseminars.org/Program-2024...

#WorldwideSodiumChannelSeminars
#Heart
#Sodiumchannel

Tomorrow Dr. Carol Ann Remme will shed light on the specificities of membrane targeting of #sodiumchannel in #cardiomyocytes 🫀

#WorldWideSodiumChannelSeminar

link will be available here: sodiumchannelseminars.org/Program-2024...