Inhibition of sterol transport protein function Intracellular sterol transport proteins (STPs) are key regulators of cholesterol homeostasis and potential drug targets in a broad range of diseases i…

Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here Hogan, Laura and Thomas describe in detail our assay cascade (including step-by-step protocols) to identify inhibitors of sterol transport proteins. (1/2) www.sciencedirect.com/science/chap...

Engineered elicitin protein enhances Phytophthora resistance in plants by dual immune induction and pathogen inhibition - Stress Biology Phytophthora pathogens are devastating agricultural threats that cannot synthesize sterols and must scavenge them from host plants. This study exploits their sterol auxotrophy by engineering a dual-fu...

Engineered elicitin protein enhances Phytophthora resistance in plants by dual immune induction and pathogen inhibition

Zhengpeng Li, Yong Pei ... Zhiyuan Yin, Daolong Dou

link.springer.com/article/10.1...

#Sterol #PTI #PlantImmunity

Evolutionary insights into the selectivity of sterol oxidising cytochrome P450 enzymes based on ancestral sequence reconstruction. The cytochrome P450 (CYP) enzyme CYP125A1 is a crucial enzyme for the long-term survival and pathogenicity of Mycobacterium tuberculosis. CYP125 genes are found not only in pathogenic mycobacteria but...

New paper in chemical science on #p450 #sterol oxidation.
@chemicalscience.rsc.org

doi.org/10.1039/D5SC...

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters Sterol transport proteins (STPs) play a pivotal role in cholesterol homeostasis and therefore are essential for healthy human physiology. Despite rece…

This one is for the #lipidtime and #sterol enthusiasts: Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters, now published in the Journal of Lipid Research: sciencedirect.com/science/arti... 1/5