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Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice.…

“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...

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New data that #pericyte contraction due to increased compression (pressure), such as occurs during acute #myocardial #infarction, depends on TRPM channels, #TRPM4 and #TRPM7. TRPM4 inhibition reduced infarct size in a mouse MI model.
doi.org/10.14814/phy...

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For #MS #MultipleSclerosis, we are often told to avoid boosting the immune system using #zinc. BUT see my recent post discusses affect of #TRPM7 on zinc #homeostasis. This morning another gene variant affecting zinc levels and contributing to #autoimmune disease. Screen shot from article. 🧵

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“Key factor in anoxic neuronal death.”

“Key factor in anoxic neuronal death.”

More on #TRPM7, which unlike #TRPM6, is heavily expressed in #neural cells.

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I believe these variants are very likely expressed in some #pwMS as well. Not causative, as spasticity. Do you have #MultipleSclerosis #MS #highbloodpressure #arterialstiffness?

pmc.ncbi.nlm.nih.gov/articles/PMC...

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More on #TRPM7 “Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases” doi.org/10.1111/imm.... free access.

“A growing body of evidence highlights the critical role of TRPM7 in autoimmue diseases, including #rheumatoidarthritis, #MultipleSclerosis and #diabetes.”

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