The words “breakthrough” and “high-impact” and “game-changing” get bandied around an awful lot, but this is one of the rare instances when they apply 💯. Amazing news for #HAT/#SleepingSickness, less so for #Tbrucei. 👏👏👏

Really quite hard to overstate what a massive development this is in the fight against #Tbrucei & #SleepingSickness, and one that comes relatively soon after #fexinidazole too 🤩. Plus, #acroziborole is active against both early and late forms, so no lumbar punctures needed. Game-changer😊👇

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively tra...

I am delighted that the preprint of my PhD work is out! We used Cas9-based method to edit essential polycistronic histone H4 gene in T. brucei for the first time. A big thanks to @fariatrypslab.bsky.social who was a fantastic mentor during my PhD
www.biorxiv.org/content/10.1...
#tbrucei #epigenetics