Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity - Nature Communications Circuit and cell type prioritization for complex disorders is crucial to direct future efforts. Here the authors integrate GWAS, human single-cell RNA-seq and fMRI analysis suggesting multi-modality c...

"Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity" #Neuroscience #Neurobiology #Psychobiology #Genomics #Metabolomics #TheScienceHusbands

www.nature.com/articles/s41...

The person-to-person transmission landscape of the gut and oral microbiomes - Nature Data from more than 9,700 human stool and oral metagenomes has been used to decipher the strain transmission patterns of the human microbiome from mother to infant, within households and within p...

"The person-to-person transmission landscape of the gut and oral microbiomes". #Microbiome #Psychobiology #TheScienceHusbands

www.nature.com/articles/s41...

Direct conversion of human umbilical cord mesenchymal stem cells into dopaminergic neurons for Parkinson's disease treatment Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits due to the depletion of nigrostriatal dopamine. Stem cell dif…

"Direct conversion of human umbilical cord mesenchymal stem cells into dopaminergic neurons for Parkinson's disease treatment". #Neurobiology #Psychobiology #TheScienceHusbands

www.sciencedirect.com/science/arti...

Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For many people living with profound auti...

“In this review, we discuss 3 genetic variants of CAMK4 found in individuals with hyperkinetic movement disorder and comorbid neurological symptoms including autism spectrum disorder that are likely pathogenic with monogenic effect”. #MentalHealth #Autism #TheScienceHusbands

Glutamatergic Medications for Obsessive-Compulsive and Related Disorders This systematic review and meta-analysis evaluates the association of glutamatergic medications with symptoms of obsessive-compulsive and related disorders as monotherapy or as augmentation to selecti...

“These findings indicate that glutamatergic medications may be effective in treating OCRDs, particularly OCD. However, high heterogeneity and potential publication bias necessitate cautious interpretation”. #MentalHealth #TheScienceHusbands

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Genomics yields biological and phenotypic insights into bipolar disorder - Nature Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Estudio genético gigantesco en pacientes con trastorno bipolar. #Genomics #BipolarDisorder #TheScienceHusbands

www.nature.com/articles/s41...

Perturbations in Gut Microbiota Composition in Psychiatric Disorders This systematic review and meta-analysis reviews gut microbiota alterations in general adult psychiatric populations and performs a within- and between-diagnostic comparison.

Interesante meta-análisis relacionando filos, familias y géneros de bacterias presentes en la microbiota intestinal con diferentes trastornos psiquiátricos. #TheScienceHusbands

jamanetwork.com/journals/jam...

Mi esposo y yo en El Río Hotel en Doradal, Antioquia - Colombia #TheScienceHusbands

Mi esposo y yo en un atardecer de Santa Marta - Colombia. #TheScienceHusbands