Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF Upstream open reading frames exert translational control of TNFR1, which limits tissue responsiveness to TNF.

I am delighted that our study “Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF”, led by Biao Ma, is published in Science Immunology.

#TNFR1, #inflammation, #CellDeath, #Immunopathology, #Tissue_tolerance
@sic-ucph.bsky.social @ludwigcancer.bsky.social

doi.org/10.1126/scii...