FF 89 Top Stories of 2025 — NephJC I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year.

#TopNephrology stories of 2025

the podcast is out: www.nephjc.com/freelyfilter...

with @kidneyboy.bsky.social @captainchloride.bsky.social @medpeedskidneys.bsky.social @annagaddy.bsky.social @vipvargh.bsky.social @brianrifkin.bsky.social & @nephroseeker.medsky.social

Survey monkey

You should have received an email like this!

Please vote (rank voting!) to choose the top 10 stories of 2025!

#TopNephrology #NephJC

Which were the Top Nephrology Stories of 2024? — NephJC Time to vote for the Top Stories of 2025

The lineup of the #TopNephrology stories is live www.nephjc.com/news/2025/11...

If you want to vote, you need to be signed up for the #NephJC Newsletter here www.nephjc.com/newsletter ASAP

Which were the Top Nephrology Stories of 2024? — NephJC Time to vote for the Top Stories of 2025

👇Here are the proposals for the #TopNephrology stories in 2025

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www.nephjc.com/news/2025/11...

FDA

That was quick!

The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA

www.fda.gov/drugs/novel-...

#NephSky

#TopNephrology

Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis - PubMed National Kidney Foundation and National Institute of Diabetes and Digestive and Kidney Diseases.

This is beyond #TopNephrology it's not only shows what nephrologists have been saying for years, but also for all of medicine to know: proteinuria is a marker of both kidney and cardiovascular disease
#Medsky

pubmed.ncbi.nlm.nih.gov/41183334/

Figure 1.1

The ongoing decline in dialysis incidence in the US

usrds-adr.niddk.nih.gov/2024/end-sta...

#TopNephrology

NIDDK webpage

The NIDDK turns 75 diabetesjournals.org/care/collect...

Just as with restructuring they cannot even update the website www.niddk.nih.gov

#TopNephrology

Soluble urokinase receptor is a kidney-specific vasoconstrictor - PubMed Supported by the National Institutes of Health, University of Southern Denmark, Region of Southern Denmark PhD Fund, OUH-RH Joint Research Fund, Danish Kidney Association's Research Fund, Odense University Hospital Research Fund, Goldsmith A. L. Rasmussen Memorial Fund, Dept. of Anaesthesiology-Inte …

SuPAR causes renal vasoconstriction and may cause AKI? pubmed.ncbi.nlm.nih.gov/41187619/ what do you say @christosargyrop.bsky.social

#TopNephrology

Kidney Week in Houston: Day 2 — NephJC in this edition: Fish Oil, GBD, Flozination meta-analysis, CHW intervention in Hispanic/Latino patients, and much more

And a low tech solution, using community health workers helps reduce ID Weight Gain
@cervantes-lily1.bsky.social

And the GBD finally tackles CKD? @paddymark.bsky.social

www.nephjc.com/news/kidneyw...

#TopNephrology

a close up of a man 's face with a beard looking at the camera . ALT: a close up of a man 's face with a beard looking at the camera .

And how about the SMART C data dump in @jama.com from @brendonneuen.bsky.social

Flozins work for everyone #TopNephrology

And we should have GLP1RAs

We have not had a huge kidney trial - but we had REMODEL, the SURPASS CVOT drop and more?

#TopNephrology

A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial Among adults at high risk for AKI undergoing major surgery, a preventive care strategy consisting of supportive measures and avoidance of nephrotoxins significantly reduced the occurrence of moderate ...

Another Zarbock positive trial!

www.thelancet.com/journals/lan...

BIGPAK2

#TopNephrology

I think ACHIEVE still deserves to be there - it did achieve answering the MRA question definitively? We can’t just choose PISCES but ignore ACHIEVE?

#TopNephrology

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease | NEJM Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access...

I know it’s been there before - but this still remains exciting
Xenotransplantation
- NEJM paper www.nejm.org/doi/full/10....
- FDA allows clinical trials

#NephJC #TopNephrology

Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica... In participants with chronic kidney disease at increased risk of disease progression, a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin alone in reducing albumin...

I'm not sure yet, because I think many similar studies will come: one step closer to GDMT implementation- CONFIDENCE and MIRO-CKD trials #TopNephrology

www.thelancet.com/journals/lan...

From progression to remission: a new paradigm for success in chronic kidney disease Recent advances in treatment of chronic kidney disease have changed the clinical paradigm from slowing inevitable progression to achievable remission. Landmark trials involving sodium-glucose cotransp...

Also, to mention: the change of perspective in nephrology- aiming for remission, not just slowing CKD 🐌 #TopNephrology

@kidneyint.bsky.social editorial by @brendonneuen.bsky.social and co

www.kidney-international.org/article/S008...

A worthy mention is the Nobel prize winner! #TopNephrology
www.youtube.com/watch?v=vUut...

Peripheral immune tolerance, in our case: how to use it to induce chimerism. #NephJC take on ongoing & finished human kidney transplant studies

www.nephjc.com/news/2025/30...

KDIGO 2025 ADPKD Guidelines Review — NephJC This week, we will discuss the first iteration of KDIGO’s 2025 guidelines on ADPKD.  These guidelines are a result of a decade of global collaboration between physicians, researchers, advocates, ...

@kdigo.org ADPKD guidelines: because they are the first global guidelines for a genetic kidney-related disease #TopNephrology

www.nephjc.com/news/adpkd-k...

And also the top in 2011
(Read the comments here www.renalfellow.org/2011/12/25/t...)

#TopNephrology

SuPAR predicts AKI in COVID-19 With apologies to AA Milne When suPAR was one, It had just begun. Telling us all that FSGS was won. When it was two, It was nearly new. And lucky for us, was explaining CKD too. When I was three, I was hardly me. Because now I was predicting mortality in diabetes you see. When I was four, I was not much more. But predicted mortality in dialysis patients for sure. When I was five, I was just alive; I was implicated in AKI, and therefore my use could thrive. But now I am six, I'm as clever as clever. Because I predict AKI in Covid-19 infection, And that’s going to be around for ever and ever So I think I'll be six now. At least until Top Nephrology Stories 2021.

It has made several appearances on #TopNephrology!

2020 (2nd position)

FLOW was the topic story of 2024!
(Agree with you though)

#TopNephrology

Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study Iptacopan showed a statistically significant, clinically meaningful proteinuria reduction in addition to RAAS inhibitors and immunosuppression at 6 months. Iptacopan was well tolerated with an accepta...

In other news?

- The (ongoing?) dawn of ASIs
- Iptacopan in C3GN www.thelancet.com/journals/lan...
- BEDMED

#TopNephrology

Lots!

From the #NephJC discussions:

- Fish oil in dialysis
- All the IgA trials
- ACHIEVE
- the 2025 @ahascience.bsky.social guidelines
- REGENCY

#TopNephrology

In ESRD is spironolactone an overACHIEVEr? — NephJC This week, we will discuss the ACHIEVE trial. Will spironolactone achieve CV benefits in ESRD?

Let's start an atypical-negative study, still practicing changing- ACHIEVE trial #TopNephrology #NephJC

www.nephjc.com/news/achieve

Top Stories in Nephrology 2024 — NephJC Should we call 2024 the Renaissance of nephrology? It was probably the richest year in RCTs in the nephrology world, reflected in the higher number of Late-Breaking Clinical Trials sessions at every b...

Every year, #NephJC celebrates successful, practice-changing trials. ✨ Which trials do you think are deserving for #TopNephrology 2025? #nephsky

👇👇 Here's a throwback for 2024
www.nephjc.com/news/2024/1/...

Beyond race and competition, its worthwhile to ponder if society is ready for pig kidneys. Ethical issues remain an important consideration (discussed nicely in Cooper et al, JASN 2020) especially around who should qualify (or risk) for these. Presently, the U.S. Food and Drug Administration is granting emergency approval for these through its single patient investigational new drug (IND) “compassionate use" pathway. Lastly - what will be the cost of these xenotransplants? Surely Revivicor and eGenesis are not doing these from the goodness of their heart (or kidneys). Beyond genetic engineering, the cost of maintaining the pristine environment in the pig farms is extraordinary. So are the costs of the expensive monoclonal antibodies that are still needed despite the genetic legerdemain conjured to make this possible. Though it often feels like change happens very slowly, and then suddenly, we may not be in the ‘suddenly’ curve of xenotransplantation yet. At least as far as its use beyond curious case reports to widespread implementation is concerned.

Sad news - kidney had to removed from Towana Looney

www.science.org/content/arti...

My skepticism around xenotransplantation remains alive: www.nephjc.com/news/2024/1/... (story 5 from #TopNephrology for #NephJC)

Top Stories in Nephrology 2024 — NephJC Should we call 2024 the Renaissance of nephrology? It was probably the richest year in RCTs in the nephrology world, reflected in the higher number of Late-Breaking Clinical Trials sessions at every b...

3/ Here is the #topnephrology blog #Medsky #NephSky

www.nephjc.com/news/2024/1/...

FF 77 Top Nephrology Stories 2024 Podcast Episode · Freely Filtered, a NephJC Podcast · 26/02/2025 · 1h 12m

Just. about to go to sleep (middle of the night for my timezone), and the top stories @freelyfiltered.bsky.social just dropped out, so will sleep later #topnephrology #NephJC

🎙️ First time @glombandit.bsky.social, lovely to hear again @rheaultm.bsky.social 💕

podcasts.apple.com/ro/podcast/f...

#NephMadness 2024 Champion: Gila Monster Nephrons, we are ready to name the 2024 NephMadness Champion as voted by the Blue Ribbon Panel. Check out the Final Standings and tweet your reactions with #Nephmadness! And as always, special than…

56/ Are you ready for number 1 #TopNephrology?

Not much of surprise I guess, the Clue is Gila Monster #NephJC

It was #NephMad ness winner after all ajkdblog.org/2024/04/08/n...