#ICYMI

#NewRelease

The Deal Maker by @louisebay.bsky.social is #NowLive on Amazon and #KindleUnlimited.

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#TopRead #bookrecs #releaseboost #sexyreads #KUbooks #KindleUnlimited #oppositesattract #mustread #AuthorLouiseBay #readingisourpassion

HAPPY BOOK WEEK: THE DEAL MAKER BY LOUISE BAY #NewRelease The Deal Maker by Louise Bay is #NowLive on Amazon and #KindleUnlimited. "...a witty, heartbreaker full of irony and temptation....

HAPPY BOOK WEEK: THE DEAL MAKER BY @louisebay.bsky.social

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#TopRead #bookrecs #sexyreads #KUbooks #KindleUnlimited #oppositesattract #mustread #AuthorLouiseBay #readingisourpassion

The World Cup is supposed to inspire hope and unity. This one feels different (Gift Article) The military action taken against Iran is the latest serious political issue overshadowing a tournament that starts in 101 days

The World Cup is supposed to inspire hope and unity. This one feels different www.nytimes.com/athletic/707... #TopRead

Data show that BRGSF-HIS mice possess human myeloid and lymphoid cell compartments in the lung interstitium comparable to humans, providing an opportunity for studying immune mechanisms of human lung diseases. This #TopRead is a collaboration led by Dr. Doumet Georges Helou: ow.ly/c5JL50XYaBP.

Data indicate that human CD4+ mucosal-associated invariant T cell TCRs may be selected by alternative MR1 ligands in addition to canonical riboflavin intermediates. Find this #TopRead article from @charlesvorkas.bsky.social and team online: ow.ly/hcNc50XYarT.

This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.

Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections The Editors have selected this article as a highlight of the issue.

New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.

The role of VISTA engagement in limiting neutrophil-mediated inflammation The Editors have selected this article as a highlight of the issue.

Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo

An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.

In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.

Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3

A novel TOX-nanoluciferase reporter mouse for exploring modulators of T cell exhaustion The Editors have selected this article as a highlight of the issue.

Another #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.

Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages The Editors have selected this article as a highlight of the issue.

June #TopRead from @ualberta.bsky.social and @wchriuofa.bsky.social found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm.

Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity The Editors have selected this article as a highlight of the issue.

A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: ow.ly/gBgR50WiiCr.

A group of five smiling individuals stands in front of a light blue background with a faint illustration of shelves and files. From left to right: A bald man with glasses and a plaid shirt, a woman with long dark hair and glasses wearing a patterned scarf, a woman with dark hair in a blue top, a woman with shoulder-length brown hair and a pink scarf, and a man with short dark hair and a dark athletic jacket.

The last May #TopRead from Dr. Ibrahim Hatipoglu found 2 lung-resident CD11b+ cDC2 subsets present in naïve mice that elaborated distinct and common functional responses regulated by IRF4 during IAV infection. Learn more: ow.ly/ksoE50W0aXS.

Today’s #TopRead Article in May from #ACareyLab at #DrexelMedicine provides insights on the age-specific role of cathelicidin-related antimicrobial peptide (CRAMP) in influenza viral pathogenesis. Learn more: ow.ly/S2cb50W0eR5

Magic cross piercing - Wikipedia

The 4th Top Read article on Wikipedia happens to be《Magic cross piercing》which is this super painful male genitalia modification, involving inserting straight barbells through the glans.

WHY?

#Wikipedia #MessedUp #Monday #Reading #MaleGenitalia #Modification #TopRead #MagicCrossPiercing #Piercings

In this April #TopRead Dr. Parvathi Ranganathan at @osuhematology.bsky.social identified dehydrogenase inhibition as an innovative treatment strategy in allo-HCT recipients to reduce graft-vs-host-disease severity while retaining graft-vs-leukemia response. Learn more: ow.ly/K7LK50VJIiW.

Exploring the genetic mechanisms driving KIR diversification The Editors have selected this article as a highlight of the issue.

A #TopRead article from Dr. Jesse Bruijnesteijn found that a diverse repertoire of killer cell immunoglobulin-like receptors (KIRs) contributes to the protection of individuals and populations against pathogen evasion and subversion. Read it in The JI: ow.ly/vJRk50VJI7H

Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life The Editors have selected this article as a highlight of the issue.

This #TopRead article in April from Dr. Joan Cook-Mills at Indiana University Medical School found that although eosinophils are not necessary during oral food allergen-induced anaphylaxis, they play a critical role in the early development of food allergy.

🔗 ow.ly/1eqI50VJHT0

#FoodAllergies

High-salt diet drives depression-like behavior in mice by inducing IL-17A production The Editors have selected this article as a highlight of the issue.

#TopRead: Data indicates a high-salt diet drives #depression by inducing the production of IL-17A and identified gamma-delta T17 cells as a key source of IL-17A. Xiaojun Chen says the work supports novel interventions and therapeutics. Read more: ow.ly/5FWX50VJHZJ.

Our final March #TopRead is from Dr. Carl Ware, @sbpdiscovery.bsky.social, who described the first method to directly quantify the HVEM-BTLA cis-complex. Find it in The JI: ow.ly/nElT50VAjzY.

CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance The Editors have selected this article as a highlight of the issue.

#TopRead and #clinical study from Dr. Celestine Wanjalla, MD PhD, found that circulating CD3+ T-cell: CD14+ monocyte pairs may contribute to inflammation and cardiometabolic disease pathogenesis, potentially originating or maintained by chronic viral infections.

🔗 ow.ly/X37Y50VAjr8

Myeloid-derived IL-33 drives γδ T cell–dependent resistance against cutaneous infection by Strongyloides ratti The Editors have selected this article as a highlight of the issue.

Today’s #TopRead from Dr. De’Broski R. Herbert investigated mice infected with the parasitic helminth Strongyloides ratti to understand mechanisms of anamnestic immunity at the skin barrier, uncovering an unknown mechanism of type 2 immunity. Find it here: ow.ly/EHth50VAjc6.

Our next March #TopRead is from Dr. Lewis Lanier and is the final paper of his career, demonstrating that SYK deletion in NK cells resulted in robust cytotoxic activity and cytokine production, providing a new strategy for cancer immunotherapy. Read more: ow.ly/UmtX50VAj25.

#Lovethisseriessomuch
#topread
#mostwanted

@elliottroseauthor.bsky.social

A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome The Editors have selected this article as a highlight of the issue.

We’re sharing the #TopRead articles from March! Read Dr. Gennaro’s research, which found that some kids with multisystem inflammatory syndrome carried rare heterozygous variants of LYST that may be a potential driver of #LongCOVID: ow.ly/REtf50VAiPG

Gene-modified NK cells expressing CD64 and preloaded with HIV-specific BNAbs target autologous HIV-1–infected CD4+ T cells by ADCC The Editors have selected this article as a highlight of the issue.

This week we’ll be sharing #TopRead articles from March, but #ICYMI a top read in Feb. From @wistar.org found that BNAb-preloaded CD64-transduced NK cells showed enhanced ability to mediate ADCC against HIV-1–infected CD4+ primary T cells. Read here: ow.ly/lRZa50VAiJA.

If you haven’t read Quicksilver yet, it is time! 💕🔥 #quicksilver #love #books #booksky #fantasy #romantasy #read #obsessed #perfect #topread