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Physiological aging in three dimensions 101

Cell type-specific aging trajectories
3D genome folding
A/B compartment switch/score variation/interaction
TAD boundary alteration
Enhancer-promoter rewiring

#TrendsCellBio 2026
www.sciencedirect.com/science/arti...

The dark proteome: translation from noncanonical open reading frames

1⃣5'-UTR 2⃣3'-UTR small ORF/sORF
3⃣out-of-frame 4⃣In-frame overlapping ORF

Translating micropeptide <100aa, proteins distinct from canonical ORFs, or isoforms

#TrendsCellBio 2022
www.sciencedirect.com/science/arti...