Infographic comparing a ketogenic diet and ketone supplementation: therapeutic ketogenic vs standard high-carb diet with added ketones, showing impacts on cellular autophagy, body size, reduced fertility, and delayed development in fruit flies.

#DBfeature 🪰

Ketone body supplementation into a standard high-carbohydrate diet reduces fecundity, delays larval development, and may induce autophagy in Drosophila melanogaster

By Meredith Becher, Fangyi Coco Zhai, et al

tinyurl.com/3uwwbfhb

Quantitative assessment of #Hypertension & Blood Pressure as a risk for #AorticDissection at Population level

J-SHC >500k, 4 y f/up, 84 events -AD mortality
UK Biobank >500k, 9 y f/up, 182 events -AD incidence
+Meta-analysis 6 prev studies

#AortaEd
#CircAHA 2021
www.ahajournals.org/doi/10.1161/...

✨ Excited to host invited speaker Jeffrey Barrow from Brigham Young University at #2026SDB in Las Vegas! 🎰🃏 His research explores the genetic and molecular mechanisms that guide organ development and patterning. 🧬🔬🧠✨ #devbio

SoLo, a source localization algorithm for super-resolution that works with either single images or fluctuating time series (a la eSRRF): arxiv.org/abs/2604.20248
Github code: github.com/M-R-Wang/SoLo

GeneBench: Assessing AI Agents for Multi-Stage Inference Problems in Genomics and Quantitative Biology Jeremy Li1,2,† , Andrew Ho1,† 1OpenAI 2Herasight April 23, 2026

Revealing potential therapeutic targets in membranous nephropathy
doi.org/10.1172/jci....

Using a multi-omic approach in a murine model of MN, Huang et al. elucidate the action of anti-THSD7A autoantibodies in the kidney in the context of autoimmunity.

Congratulations on this great work🥳🥳🥳

Power & Elegance of CODA
Whole-embryo🐵🐭🐢Vessel-Nerve Network
Form-Function Coupling

Vessel
Scale-invariant▶️branch radius length
Space-filling
Fractal 3

Nerve
Less strict self-similarity
Optimized electrical conduction
Fractal 2

@deniswirtz.bsky.social bioRxiv 2026
www.biorxiv.org/content/10.6...

Creative and elegant work - and well-told @deeparajan.bsky.social @wallaceucsf.bsky.social

#DBfeature #SeaUrchin 🌊

Germline factors, TDRD & Piwi, colocalize with Vasa on the mitotic apparatus during the embryogenesis of the sea urchin

by Mariana Witmer, Mamiko Yajima et al
www.sciencedirect.com/science/arti...

Extracellular Vesicle Proteomics of p21+ Senescent A549 cell (bleomycin)

Inhibition of EV biogenesis by GW4869 does not change soluble SASP

Isolated EV from senescent A549 is sufficient to drive Paracrine Senescence of proliferating A549 cells

bioRxiv 2026
www.biorxiv.org/content/10.6...

Extracellular Vesicle Proteomics of p21+ Senescent A549 cell (bleomycin)

Inhibition of EV biogenesis by GW4869 does not change soluble SASP

Isolated EV from senescent A549 is sufficient to drive Paracine Senescence of proliferating A549 cells

bioRxiv 2026
www.biorxiv.org/content/10.6...

Presenting a resource for scientists to study the cellular landscape of the eye in health & disease: doi.org/10.1172/jci....

This issue’s Cover: Colin J Chu @colinchulab.bsky.social & team @ucl.ac.uk detail a new spatial proteomic atlas of the mouse & human retina.

Interested in Physics of Life? Curious about what are the scientific questions we study at @poldresden.bsky.social ? You can learn that in less than 3 min 🤩👇

Thanks to Avanga Film production for the great video 🎬

😁

Harmony2 required only 2.1 GB and 1.3 minutes per million cells, and "scales linearly", and can integrate the full Tahoe-100M dataset & Human Lung Cell Atlas (Hierarchical integration)

vs Harmony scVI ComBat-seq Seurat-RCA LIGER

bioRxiv 2026
www.biorxiv.org/content/10.6...

Congratulations on this super-cool preprint!👍
Will read & learn😆

All you ever wanted to know about how to analyse the nematic nature of cellular tissues is right here 👀👇🏼!

Bonus #1: we did it for many cell types and uncovered unexpected defect behavior 🐌

Bonus #2: for theoreticians looking for parameter values for your simulation🧑🏼‍💻

tinyurl.com/2s399yen

A review on Super-resolution Structured Illumination Microscopy (SIM) to study endocytosis: pubs.acs.org/doi/10.1021/...
Featuring our live-cell SIM of proximal axons showing frozen clathrin-coated pits within clearing of the spectrin mesh (doi.org/10.1126/scie...)

#erc | Johanna Joyce What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

What should Europe do when demand for #ERC funding keeps rising?
Restrict access or invest in excellence?

Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness

Consider to share & sign - see below 🧪

very interesting read even though you're not into nematics

Building baby’s first maze: doi.org/10.1172/jci....

In this Research Article, Derek C. Sung & team use a mouse model in which Dll4 was deleted only in the placental vasculature to show an essential role for notch-chemokine signaling in assembling the placental vasculature.

Sex-specific dysregulation of cardiac-enriched microRNAs with age in Drosophila melanogaster | American Journal of Physiology-Cell Physiology | American Physiological Society Dysregulation of cardiac-enriched microRNA (miRNA) expression is linked to age-associated cardiovascular diseases (CVDs). However, the sex-specificity and age at which dysregulation occurs remain uncl...

Varghese, L. N., Sheard, P. W., Schwenke, D. O., Katare, R. (2025). Sex-specific dysregulation of cardiac-enriched microRNAs with age in Drosophila melanogaster Am J Physiol Cell Physiol, 328(6):C1743-c1751 journals.physiology.org/doi/full/10....

Influenza A virus induces Lung cell senescence in vivo

Infected macrophage conditioned medium⏩
Paracrine Senescence of lung fibroblast (IMR90)

Lung fibroblasts+TNFα are susceptible to IAV infection
~4.5-fold⏫viral titer
⏫IAV nucleoprotein

#AgingDis 2023
www.aginganddisease.org/EN/10.14336/...

✨ Excited to host invited speaker Leslie Babonis at #2026SDB in Las Vegas! 🎰🃏 Her research uncovers how evolutionary innovations shape developmental biology, with a focus on cell type diversity and the origins of complex traits. 🧬🌊🔬✨ #devbio

Don't use an LLM to send emails to professors. Send us the prompt you used instead please, it will be more intelligible.

Two plots, showing a biosensor response. Both report a 'dynamic range', one referring to the biosensor affinity and one referring to the optical signal.

TIL "dynamic range" is used for two orthogonal biosensor properties.
Which one is correct?

👏👏👏

Parafibromin/Hyrax Activates Wnt/Wg Target Gene Transcription by Direct Association with β-catenin/Armadillo The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of β-catenin with nuclear TCF/LEF proteins…

#OTD 20 (!) years ago - the first paper from my thesis work came out. Feels like yesterday.

Great memories with George Hausmann and Koni Basler. From a time when new Wnt pathway components could still be found - thx to Drosophila!

Onwards, always.

www.sciencedirect.com/science/arti...

just got knocked over by this new paper from the Andrei Chagin lab: www.science.org/doi/epdf/10....

physically dropped the paper in delighted surprise when I got to the second half of Fig 5: