GLP-1/GIP/GCG receptor triagonist (IUB447) enhances insulin secretion via GLP-1 receptor and Gαq signalling pathway in mice - Diabetologia Aims/hypothesis Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glyc...

Triagonist IUB447 promotes insulin secretion in mouse islets via GLP-1R activation and Gαq/TRPM5 signalling. Insights into tri-receptor co-activation!
#DiabetesResearch #IsletBiology #Triagonist #GPCR #TRP link.springer.com/article/10.1... 🔓