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American Heart Association Journals

This does not mean preeclampsia has one cause.

It shows what progress looks like when we move from describing a syndrome to arguing a defensible mechanism.

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Link: www.ahajournals.org/doi/10.1161/...

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This is not about slowing innovation.
It is about catching surprises earlier and making safety claims more defensible, for both ex vivo and in vivo editing.

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An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs - Nature Cell Biology Yu et al. identify HELDR as a lncRNA co-amplified with EGFR in glioblastoma to promote a KAT7-activated malignancy programme, which can be potentially targeted with anti-EGFR therapy for improved ther...

The annotation of what rides alongside a driver oncogene deserves the same attention as the driver itself. Not as a secondary analysis, but as part of the primary question.

Full paper: www.nature.com/articles/s41...

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6/ Next up: the analytical and experimental approaches that made this finding possible, and why they are easy to get wrong.

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❓ As methods improve, do you feel optimistic that we can turn fragmented cfRNA into biologically meaningful insight, or still pushing against fundamental signal limitations?

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Strong RNA‑seq studies make that boundary explicit before reviewers force the issue.

That’s where judgment and experience matters more than tools.

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Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease Crohn's disease (CD) involves chronic transmural inflammation of the intestines, leading to progressive wall fibrosis with stenosis and luminal obstruction, predominantly in the terminal ileum. Fibro...

That’s why good RNA‑seq instruction isn’t about tools alone, it’s about learning how to reason from data to biology with confidence.

(Example study we referenced earlier 👇)
🔗 pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...

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Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease Crohn's disease (CD) involves chronic transmural inflammation of the intestines, leading to progressive wall fibrosis with stenosis and luminal obstruction, predominantly in the terminal ileum. Fibro...

A recent Crohn’s disease study combining pathology + scRNA‑seq is a good illustration of both the power and the responsibility that comes with this approach.

🔗 pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...

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