Research demonstrates that dysregulated #Notch signaling promotes #TumorAngiogenesis in #ESCC via the NOTCH1–USP5–STAT3 axis, suggesting that targeting this pathway could inhibit #TumorVascularization and progression.

#STTT #OpenAccess: doi.org/10.1038/s413...

Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication

A comprehensive overview of the origins of #EndothelialCells in hypoxic & #TumorAngiogenesis, the key regulatory molecules, with discussion of the advances, challenges, and future directions of #AntiAngiogenicTherapy.

#OpenAccess: doi.org/10.1016/j.ge...

In #ESCC, aberrant #NotchSignaling promotes #TumorAngiogenesis through the NOTCH1–USP5–STAT3 axis, with #USP5 stabilizing #STAT3 to enhance pro-angiogenic factors, and targeting USP5 alongside #chemotherapy suppresses tumor growth.

#OpenAccess #STTT: doi.org/10.1038/s413...

Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication

An extensive review on the origins of endothelial cells in #TumorAngiogenesis, the key molecules & signaling pathways regulating the angiogenic process, with highlights on the progress, limitations, & future directions of #AntiAngiogenicTherapy in #cancer. #medsky

#OpenAccess: buff.ly/lqMjFep