New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵

The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...

Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...

Evaluating evidence for UFMylation client diversity - Nature Reviews Molecular Cell Biology The small ubiquitin-like modifier UFM1 is known to regulate the ribosomal subunit RPL26, but whether other bona fide substrates exist remains debated. This Comment discusses criteria for the experimen...

Such a pleasure to share our commentary on #UFMylation client diversity published in @natrevmcb.nature.com. Thanks to @lisaheinke.bsky.social for the opportunity to write it, reviewers for their peer review contribution, and members of our lab for discussions.
Link: www.nature.com/articles/s41...

Client Challenge

A very nice #review on #UFMylation from the giants of the field: The mechanistic basis and cellular functions of UFMylation www.nature.com/articles/s41...

Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression
www.embopress.org/doi/full/10....

Diagram showing how UFL1 interacts with flaviviral NS2A, Capsid, and NS3 proteins to promote viral assembly.

Excited to share our new paper led by recent PhD, Dr. Hannah Schmidt! We found that UFMylation unexpectedly promotes flavivirus particle production by specifically regulating viral assembly. Check it out! #virology #UFMylation #flaviviruses
journals.asm.org/doi/10.1128/...

The many connections of UFMylation with Alzheimer’s disease: a comprehensive review - Molecular Neurodegeneration Alzheimer’s disease (AD) is a complex neurodegenerative disorder that is characterized by the accumulation of pathologic tau and beta-amyloid proteins. UFMylation is an emerging ubiquitin-like post-tr...

'The many connections of #UFMylation with #AlzheimersDisease: a comprehensive review'

Tingxiang Yan, Benjamin D. Clarkson, Zhenkun Lou, Wolfdieter Springer & Fabienne C. Fiesel @fabiennefiesel.bsky.social

molecularneurodegeneration.biomedcentral.com/articles/10....

🆕 #preprint by @gekaragoz.bsky.social lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) www.biorxiv.org/content/10.1... As always let us know what you think!