Integrated single-nucleus #Multiomics, SRF #ChIPseq and experimental validation identified MAPK14 as a master regulator of transcriptional remodeling in #VSMCs, providing insights into how its inhibition protects against #AbdominalAorticAneurysm.

#OpenAccess: doi.org/10.1038/s413...

#Hyperlipidemia activates C/EBPβ to drive #VSMCs toward a macrophage-like phenotype, promoting #ArterialStiffness, while C/EBPβ loss alleviates #VascularRemodeling and identifies PDGF-CC as a potential #biomarker of human arterial stiffness.

#STTT: doi.org/10.1038/s413...