ViennaRNA Package v2.7.1 is out! 🧬🎉 Solid update: smoother probing-informed folding (SHAPE/DMS), improved constraints handling, and nicer Python multistrand base-pair probs.
Get: tbi.univie.ac.at/RNA/
Source: github.com/ViennaRNA/Vi...
#ViennaRNA #RNA #ComputationalBiology #SHAPE #DMS #OpenSource

Modified RNAs and predictions with the ViennaRNA Package AbstractMotivation. In living organisms, many RNA molecules are modified post-transcriptionally. This turns the widely known four-letter RNA alphabet ACGU

Got interested? Read the full story here: academic.oup.com/bioinformati...

#RNA #Biotechnology #ViennaRNA #ComputationalBiology
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What makes the #ViennaRNA Package unique? 🤔

We don't rely on a pre-compiled, complete set of energy parameters for modified bases. Instead, we use a mix of hard- and soft-constraints to adjust predictions where we have parameters.

#RNAScience #RNABioinformatics
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Did you know? The #ViennaRNA Package can handle a wide range of RNA modifications, including:

#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)

#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
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They play vital roles in regulating gene expression by influencing processes like splicing, stability, and translation. To truly understand cellular processes and disease mechanisms, we must explore how these modifications shape RNA structure and function.

#ViennaRNA
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