Did you miss the Global Patient & Carer Symposium on #WorldKidneyCancerDay? You can watch the recording on YouTube! www.youtube.com/watch?v=-1LX... #WKCD25
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Thank you for joining us in recognising #WorldKidneyCancerDay! Follow us throughout the year for important updates related to #KidneyCancer. #WKCD25
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Join the more than 500 people who have already viewed today's Global Patient & Carer Symposium! The recording is available at www.youtube.com/watch?v=-1LX... #WorldKidneyCancerDay #WKCD25
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It's about time someone brought a sense of humour to #kidneycancer!
Well done Italy!
#worldkidneycancerday
#WKCD25
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Great and fun video on the importance of your kidneys! Remember to show your kidneys some love today and every day. www.youtube.com/watch?v=uDCz... #WorldKidneyCancerDay #WKCD25
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17/ 🎯Targeted approved agents:
⏩VEGF and its receptor (VEGFR) inhibitors- sorafenib, sunitinib, bevacizumab, pazopanib and axitinib
⏩mTORC1 inhibitors- everolimus, temsirolimus have been approved
🔗 pubmed.ncbi.nlm.nih.gov/28276433/
#WKCD25 #Medsky #Nephsky
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16/📌Management in a nutshell:
✂️Localized RCC can be successfully managed with surgery, whereas metastatic RCC is refractory to conventional chemotherapy
🔗 pubmed.ncbi.nlm.nih.gov/28276433/
#WKCD25 #Medsky #Nephsky
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15/📌Let's look at the stages of kidney cancer and their recommended treatment
🔅Staging of renal cell carcinoma (RCC) is based on size, position and lymph node involvement
🔗 pubmed.ncbi.nlm.nih.gov/25691606/
#WKCD25 #Medsky #Nephsky
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13/🔎What else can be done to maintain kidney health?
🚬Quit smoking
🏃♂️Maintain a healthy weight
🎾Be active but avoid contact sports
💦Drink enough water and WHO recommends no alcohol at all
#WKCD25 #Medsky #Nephsky
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12/⏩What are the other factors to take care of?
🔎Diabetes- Regular monitoring and strict control of HBA1c is needed
💊Other medications and supplements- tell your doctor of all the pills
🚨Is the patient Immunocompromised?
#WKCD25 #Medsky #Nephsky
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9/📌How to diagnose RCC?
🩸Clinically- flank pain, gross hematuria and a palpable abdominal mass
🔅Paraneoplastic syndromes like hypercalcemia, fever and erythrocytosis are not uncommon
🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...
#WKCD25 #Medsky #Nephsky
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8b/
✅VHL mutation and 3p loss of heterozygosity are early events evident in all ccRCC cells
🧬Common driver mutations (SETD2, MTOR and KDM5C mutations) are often present heterogeneously — suggestive of sub clonal evolution of the tumor
🔗 pubmed.ncbi.nlm.nih.gov/22397650/
#WKCD25 #Medsky #Nephsky
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8a/📌Pathophysiology
🧬Loss of VHL is the most frequent genetic feature of ccRCC
🚨It leads to aberrant accumulation of HIF proteins, uncontrolled activation of HIF target genes that regulate angiogenesis, glycolysis and apoptosis
🔗https://pubmed.ncbi.nlm.nih.gov/24491179/
#WKCD25 #Medsky #Nephsky
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7/📌Genetic factors
🧬Mutations in at least 11 genes (BAP1, FLCN, FH, MET, PTEN, SDHB, SDHC, SDHD, TSC1, TSC2, and VHL)
🧬VHL- the mutated gene underlying von Hippel-Lindau disease, is characterized by a high risk of developing ccRCC
🔗https://pubmed.ncbi.nlm.nih.gov/18039096/
#WKCD25 #Nephsky
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5/ 📌Incidence
📍Constitutes 2% of cancer diagnosis and cancer deaths 🌏
🔅Annually,
~295,000 new kidney cancer cases are diagnosed
~134,000 deaths are recorded worldwide
🔗https://pubmed.ncbi.nlm.nih.gov/26181261/
🔗https://pubmed.ncbi.nlm.nih.gov/38341277/
#WKCD25 #Nephsky
@hswapnil.medsky.social
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1/🌞Hello everyone, welcome to a🆕 #skeetorial as we celebrate World Kidney Cancer Day on 19th June
⁉️Do you know how many people worldwide are diagnosed with kidney cancer every year?
🚨Around 431,000!!
#WorldKidneyCancerDay
#WKCD25 #Medsky #Nephsky
@ikccorg.bsky.social @myadla.bsky.social
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This year’s theme for #WorldKidneyCancerDay is “show your kidneys some love”.
Visit the website for resources and more information: www.worldkidneycancerday.org #WKCD25
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Our latest newsletter is now available. Read these important updates, including for #WorldKidneyCancerDay: mailchi.mp/ikcc/newslet... #WKCD25
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Show your kidneys some love for #WorldKidneyCancerDay! Download an information sheet and discussion guide for you and your doctor: www.worldkidneycancerday.org/wp-content/u... #WKCD25
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The survey highlighted a key issue: many patients and carers are not sure of the best way to keep their kidneys healthy. That’s why this year’s theme is “show your kidneys some love”. ikcc.org/wp-content/u... #WKCD25 (2/2)
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#WorldKidneyCancerDay is this Thursday! Remember to download the Twibbon and other resources: www.worldkidneycancerday.org/resources/ #WKCD25
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World Kidney Cancer Day is fast approaching! Visit the website for a downloadable checklist for patients to take to the doctor with questions to ask about their kidney health. www.worldkidneycancerday.org #WorldKidneyCancerDay #WKCD25
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