Honoured and humbled to win Best Talk at #WNTUK2025! This work reflects years of dedication and a fantastic team effort, led by the amazing Hayley Belnoue-Davis and myself, under the brilliant Simon Leedham. Grateful to all—soon to be in press! 🚀
Really enjoyed #WNTUK2025 at @ox.ac.uk in beautiful Worcester College today. Excellent program of research talks and posters put together by @michaelranes.bsky.social and @oxfordcancer.bsky.social representing all themes, career stages and gender/diversity of @wntuk.bsky.social research. 👊
And that’s a wrap! @michaelranes.bsky.social draws a highly enjoyable, well organised and stimulating 2nd WNTUK meeting to a close, followed by drinks in the sun in front of a beautiful Worcester College lawn. See you next year!
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Congratulations to @eoghanjm.bsky.social from @ox.ac.uk on winning best talk, and Kieran Hodson from the Toby Phesse group at @cardiffuni.bsky.social @ecscri.bsky.social on winning best poster!
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The final talk of the day is our international keynote speaker @michaelboutros.bsky.social from @dkfz.bsky.social @uniheidelberg.bsky.social presenting a past and present overview on mechanisms of Wnt signal transduction.
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The penultimate talk of the day is our best selected PhD talk by Dr Ben Broadway from the Guettler lab at @icr.ac.uk presenting on CRISPR approaches to uncovering new tankyrase regulatory mechanisms in Wnt/B-catenin signalling.
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Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session!
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The final session of the day is a Future Generation focus starting with invited ECR speaker Dr Yeonjoo Kim from the @ianmcgough.bsky.social group at @babrahaminst.bsky.social presenting on a novel RASopathy caused by hyperactive non-canonical Wnt signalling.
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Final talk of the disease session is a selected abstract from Nico Mueller of the de la Roche group at @cambridgeuni.bsky.social @cruk-ci.bsky.social speaking about novel LGR5 immunotherapeutics against multiple cancer types.
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Next up another selected abstract this time from Dr Nuray Gunduz at the Sansom group at @cruk-si.bsky.social presenting her research on LGR4 maintenance of intestinal homeostasis and protection from mutant-cell clonal expansion.
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Many thanks to @yatlasi.bsky.social from @qubelfastofficial.bsky.social for chairing the Disease and Translational Research session.
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The Disease & Translational Research session begins with invited speaker Dr @vivianlilab.bsky.social from @crick.ac.uk presenting on SOX2 driven fetal reprogramming and reversible dormancy in colorectal cancer.
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Lunch break means it’s WntUK poster time!
We have 17 fabulous posters here today covering Wnt signalling across mechanisms, development and disease from all career stages.
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The final session before lunch is a selected abstract from Lee Placito Fellow of GI Cancer @eoghanjm.bsky.social from the @leedham-simon.bsky.social group at @ox.ac.uk speaking about GREMLIN1 role in stromal remodelling of Wnt-dependent ectopic stem niches in the intestine.
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Taking us into the afternoon is the third selected abstract from Dr Ines Alvarez Rodrigo from the @jpvincentlab.bsky.social at the @crick.ac.uk presenting her research on Wnt secretion mechanisms at the membrane.
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We are incredibly grateful to our kind sponsors for the day @thermofishersci.bsky.social @biologists.bsky.social @oxfordcancer.bsky.social and @cambridgebio.bsky.social
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Our invited speaker for the Wnt Signalling in Development session is Prof Denis Headon from @cmvm-edinburghuni.bsky.social presenting on Wnt signalling patterning of the Whisker Array.
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The final talk of the morning session is a selected abstract from our international guests! Dr Michaela Holzem from @michaelboutros.bsky.social lab at @dkfz.bsky.social @uniheidelberg.bsky.social presents on PI3K regulation of Wg secretion in polarised tissue.
All welcome at WntUK!
#WNTUK2025
Our first selected oral presentation comes from Elisabeth Chapman from the @melissa-gammons1.bsky.social group at the CIMR @thecimr.bsky.social telling us about her research into casein kinase 1 regulation of Wnt signalosome assembly.
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Many thanks to @matthias-krause.bsky.social from @kingscollegelondon.bsky.social for chairing the first session on Molecular Mechanisms of Wnt Signal Transduction.
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The invited speaker for the opening Molecular Mechanisms of Wnt Signalling session is fellow conference organiser Prof Yvonne Jones from Nuffield Dept of Medicine Div of Structural Biology @ox.ac.uk revealing Structural insights into the extracellular modulation of Wnt signalling
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Conference organiser and WntUK committee member @michaelranes.bsky.social from @ox.ac.uk @oxfordbiochemistry.bsky.social welcomes attendees and opens the meeting.
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Have a fabulous time at #WntUK2025 everyone! Look out for Yeon Kim, a postdoc in the McGough lab who was selected as WntUK’s first invited early career researcher 👏
We are less than a week away from the WntUK 2025 annual meeting in @ox.ac.uk @oxfordcancer.bsky.social
To all our speakers, presenters and attendees we hope your preparations are going well and we look forward to seeing you Monday at Worcester College!
Please tag #WntUK2025 in your posts!
Welcome to #2 of our 'Wnt Researcher of the Week' series where we profile an active researcher in the WntUK network!
Next up is Dr Yeon Kim, PostDoc in the @ianmcgough.bsky.social lab at the @babrahaminst.bsky.social and selected ECR speaker for #WNTUK2025
Yeon's Quickfire Q&A below 🧵1/
Early bird registration discount may have passed but #WNTUK2025 is still open for standard registration and abstract submission. Still plenty of speaker/poster slots available for all career levels and areas of Wnt signalling.
Abstract deadline Feb 1st and we are just over 8 weeks from the big day!
What better way to start 2025 than signing up for the #WNTUK2025 meeting on 24th March in @ox.ac.uk sponsored by @oxfordcancer.bsky.social and @cambridgebio.bsky.social. Early bird discount rates only available until Jan 17th and abstract deadline is Feb 1st!
www.cancer.ox.ac.uk/news/oxford-...
