#ERStress activates IRE1α–XBP1s to upregulate hIAPP transcription via an ACGT site, driving β-cell dysfunction in #type2diabetesmellitus (#T2DM); blocking #XBP1 splicing with MKC3946 lowers IAPP and improves β-cell survival.
#OpenAccess: doi.org/10.1016/j.ge...

XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation

#ERstress enhances hIAPP promoter activity by inducing #XBP1 splicing, while the disruption of the binding site or reduction of spliced XBP1 decreases hIAPP expression, resulting in improved human pancreatic β-cell survival & function. #DiabetesMellitus #medsky

#OpenAccess: buff.ly/lVnz8AH

X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D Epstein-Barr virus (EBV) establishes a latent form of infection in memory B cells, while antibody-secreting plasma cells often harbor the lytic form of infection. The switch between latent and lytic E...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"is sufficient to induce lytic EBV gene expression in lymphoblastoid B cells, as well as nasopharyngeal carcinoma epithelial cells." #XBP1 #PKD

X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D Epstein-Barr virus (EBV) establishes a latent form of infection in memory B cells, while antibody-secreting plasma cells often harbor the lytic form of infection. The switch between latent and lytic E...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"In this work, we demonstrate that the combination of the active (spliced) form of #XBP1 (XBP-1s) with activated protein kinase D ( #PKD, a histone deacetylase [ #HDAC] inhibitor that is activated following antigen receptor engagement in B cells)"

X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D Epstein-Barr virus (EBV) establishes a latent form of infection in memory B cells, while antibody-secreting plasma cells often harbor the lytic form of infection. The switch between latent and lytic E...

X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D #EBV #XBP1

pmc.ncbi.nlm.nih.gov/articles/PMC...