Exciting topline results from a #Phase2 trial in #Alz presented at #AAIC25 by #INmuneBio showing #solTNFinhibition by #XPro1595 in amyloid positive patients with 2+ biomarkers of inflammation in blood slowed cognitive decline in a 6 mo trial 🤓💪🏼💜🧠

Ablation of CCL17‐positive hippocampal neurons induces inflammation‐dependent epilepsy Ablation of CCL17-expressing hippocampal neurons induces spontaneous epileptic seizures accompanied by neurodegeneration, gliosis and behavioral changes. Inhibition of soluble TNF by XPro1595 applica...

Ablation of CCL17-positive hippocampal neurons induces inflammation-dependent epilepsy #Epilepsia #FoersterLab @unibonn.bsky.social #XPro1595; #astrogliosis; #diphtheria #toxin; #microgliosis; #neurodegeneration shorturl.at/j0BaF