Selective defluorinative [4 + 3] annulation to access fluorinated oxazepines and thiazepines Fluorinated seven-membered heterocycles are rare yet highly valuable motifs in drug discovery due to their conformational diversity and improved pharmacological profiles. Here, we present a novel, pra...

Recent research by Keyume Ablajan's team.
#XinjiangUniversity

Authors present a novel, practical, and mild base-mediated SN2′/SNV and ipso-/γ-selective defluorinative annulation of heteroaryl-based bis-nucleophiles with α-CF3-styrenes.

doi.org/10.1039/D5QO01324K