Beyond core components, we identify for the first time an extensive, diverse repertoire of auxiliary and backup effectors--consistently associated with BREX and BR systems--reinforcing restriction and countering phage anti-defense strategies #RMlike #antiphage #armsrace

How do bacteria survive phage infections? Bae et al. explore diverse #antiphage defense systems, with a special focus on the model pathogen Pseudomonas aeruginosa due to its strain diversity and genomic adaptability.
buff.ly/phnGnWL
#FEMSMicrobiolRev

Phage-encoded homing endonucleases attenuate bacterial immunity The arms race between bacteria and bacteriophages (phages) gave rise to multiple layers of antagonistic mechanisms, many of which remain unexplored. Here, we investigated the anti-phage defense system...

🚨 Happy to share our new preprint in which we explore different layers of the phage-bacteria arms race.
The highlight: phage homing endonucleases attenuate bacterial defenses 🤯
A 🧵... (1/7)
#bacteriology #antiphage #T6SS
www.biorxiv.org/content/10.1...

🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9

Scheme showing a proposed mechanism for the release of SCC cassettes and DNA molecules encoding anti-phage systems, following phage infection

SCC mobile genomic islands are known to spread #AntibioticResistance among staphylococci

This work shows that phage infection stimulates SCC mobilization & this facilitates the spread of #antiphage defenses

#microNatComms #microbiology #bacteria

Read the paper:
www.nature.com/articles/s41...