SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬
Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO
#depmap #cancertarget #syntheticlethal