Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA | Antimicrobial Agents and Chemotherapy Antimicrobial resistance (AMR) poses a growing threat to global health, contributing to an estimated 4.95 million deaths in 2019 (1). Methicillin-resistant Staphylococcus aureus (MRSA) is among the most persistent and clinically challenging pathogens, causing infections ranging from bacteremia and pneumonia to osteomyelitis and endocarditis in both healthcare and community settings. MRSA’s ability to evade multiple antibiotic classes, particularly β-lactams, has made it a priority pathogen for new treatment strategies.

Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA!

(A link between Spx and c-di-AMP 🤔)

| Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...

#cdAMP

Also doch der Turgor!

Great paper from David Rudner's laboratory!

#cdAMP #subtiwiki #subtilis

Cyclic di-AMP inhibits Listeria monocytogenes thymineless death during infection Anti-folate antibiotics are used to treat meningitis and refractory listeriosis caused by drug-resistant Listeria monocytogenes ( Lm ). Their bactericidal activity is attributed to the deactivation of...

🫴 A novel function for the c-di-AMP binding protein PstA:

👇

www.biorxiv.org/content/10.1...

#Listeria #cdAMP

Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases An RNA tool is developed for high-throughput evolution of c-di-AMP synthases from the single-molecule view.

👉 A novel biosensor for c-di-AMP: Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases:

👇👇👇

| Science Advances www.science.org/doi/10.1126/...

#cdAMP @science.org