Burkholderia cepacia ST 767 causing a three-year nosocomial outbreak in a hemodialysis unit The risk of bloodstream infections increases in patients undergoing chronic hemodialysis, primarily due to water contamination or improper handling du…

#burkholderia #cepacia outbreak in HD patients www.sciencedirect.com/science/arti...

#burkholderia #cepacia most commonly used abx is tmp-smx
-Because of R to multiple abx, successful tx requires combinations of abx+surgery
-Drug combinations that have demonstrated synergy in vitro include
tmp-smx+ceftazidime
cipro+carbapenem
ceftaz+cipro

#burkholderia #cepacia resistance to β-lactams has developed by means of an inducible chromosomal β-lactamase & altered penicillin-binding proteins. Antimicrobial efflux pumps can also lead to resistance to trimethoprim, chloramphenicol, and fluoroquinolones

During March 2016–January 2019, #Burkholderia #cepacia infection in 13 PWID in Kowloon West Region, Hong Kong, China. 7pts w/ infective spondylitis, 2 w/ IE, 2 septic arthritis, 1 intramuscular abscess/bacteremia, & 1 nec fasciitis. 11 of 13 pts required surgical treatment.

Invasive <em>Burkholderia cepacia</em> Complex Infections among Persons Who Inject Drugs, Hong Kong, China, 2016–2019 <em>B. cepacia</em> among Persons Who Inject Drugs

#Burkholderia #cepacia ubiquitous aerobic gram-negative bacillus commonly found in water, soil, and plants. Rapidly growing bacterium that can survive for a long time in harsh environments. wwwnc.cdc.gov/eid/article/...

#Burkholderia #cepacia is type species of genus Burkholderia & ubiquitous MDR, motile, non–glucose-fermenting, gram-negative organism found in water & soil. Major pathogen in cystic fibrosis & opportunistic pathogen in pts w/ indwelling medical devices & immunosuppression

Polyclonal <em>Burkholderia cepacia</em> Complex Outbreak in Peritoneal Dialysis Patients Caused by Contaminated Aqueous Chlorhexidine Polyclonal Burkholderia cepacia Complex Outbreak

Polyclonal #Burkholderia #cepacia Complex Outbreak in Peritoneal Dialysis Patients Caused by Contaminated Aqueous Chlorhexidine wwwnc.cdc.gov/eid/article/... #IDsky