First author @drjideojo.bsky.social & colleagues discovered that problems w lipid metabolism are a key feature of the intestinal lining in children with #UC & might be fixed by targeting #PPARα.

They also showed how #colonoids can be used to test therapies aimed at fixing this dysfunction.

Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio Pathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. This work combines ba...

Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.

journals.asm.org/doi/10.1128/...

Crypt Kinetics🛞

🔬Human #colonoids stained for Ki67 (marker of proliferation) in #crypts like structures. Red depicts staining of actin filaments and blue is DNA.

🎨Scientific #artwork by Naveen Parmar from @uio.no, Norway.

#intestinal #organoid #microscopy #sciart #bioart #scienceandart